Amphetamine how to make
Amphetamine how to make
Amphetamine how to make
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Making Methamphetamine at home:
Ephedrine The cottons in todays vicks nasle inhalers dont contain efed or pfed (ephedrin or psuedoephedrin) but there are still lots of easy ways to get good ephed or pfed, pure ephedrin can be extracted out of it’s plant matter, from a plant that can be bought at most garden stores. Or you can get pfed from decongestive pills like sudafed. Most people perfer to work with pfed from pills rather then ephed from the plant. The important thing is that you must have pure pfed/ephed as any contaminants will ♥♥♥♥ up the molar ratio leaving you with over-reduced ♥♥♥♥ or under-reduced ♥♥♥♥. Or contaminats will jell durring baseifying and gak up your product which will then be very hard to clean. So you want to find a pill that is nearly pure pfed hcl, or as close to pure as you can get. Also check the lable on your pills and see what inactive ingredients they contain. Inactive ingredients are things like binders and flavors. These you dont want and will remove when cleaning your pills. but certain inactive ingredients are harder to remove then others. You dont want pills with a red coating, you dont want pills with alot of cellose in them and you dont want pills with much wax. you also dont want pills that contain povidone. As a rule, if you have a two pills that contain the same amount of pfed hcl then take the smaller sized pill because it obviously has less binders and inactive ingredients, time released pills are usualy harder to work with because they have more binders and tend to gel up durring the a/b stage. Also only buy pills that have pfed hcl as the only active ingredient. You first have to make ephedrine (which is sometimes sold as meth by itself):If you are selling it. I would just make ephedrine and say it’s meth.
List of equipment : A glass eyedropper
Three small glass bottles with lids (approx. 3 oz., but not important)one should be marked at 1.5oz, use tape on the outside to mark it (you might want to label it as ether). One should be clear (and it can’t be the marked one).
A Pyrex dish (the meatloaf one is suggested)
A glass quart jar
Clean rubber gloves
A measuring cup
Preparing your Lab:
Preparing Ethyl Ether: WARNING: Ethyl Ether is very flammable and is heavier than air. Do not use ethyl ether near flame or non-sparkless motors. It is also an anaesthetic and can cause respiratory collapse if you inhale too much.
Take the unmarked small bottle and spray starter fluid in it until it looks half-full. Then fill the rest of the way with water, cap the bottle and shake for 5 minutes. Let it sit for a minute or two, and tap the side to try and separate the clear upper layer. Then, draw off the top (ether) layer with the eyedropper, and throw away the lower (water) and cloudy layer. Place the ether in the marked container. Repeat this until you have about 1.5 oz. of ether. Put the cap on it, and put it in the freezer if you can. Rinse the other bottle and let it stand.
Ethyl ether is very pungent. Even a small evaporated amount is quite noticeable.
Ephedrine & or P-Ephedrine: Please discuss this on the neonjoint forum
5. Pour 1/8 teaspoon of the lye crystals into the bottle of ephedrine and agitate. Do this carefully, as the mixture will become hot, and give off hydrogen gas and/or steam. H2 gas is explosive and lighter than air, avoid any flames as usual. Repeat this step until the mixture remains cloudy. This step neutralizes the HCl in the salt, leaving the insoluble free base (l-desoxyephedrine) again. Why do we do this? So that we can get rid of any water-soluble impurities. For 3 oz. bottles, this should take only 3 repetitions or so.
7. Let the mixture settle. There will be a middle layer that is very thick. Tap the side of the bottle to get this layer as thin as possible. This is why this bottle should be clear.
8. Remove the top (ether) layer with the eyedropper, being careful not to get any of the middle layer in it. Place the removed ether layer into a third bottle.
9. Add to the third bottle enough water to fill it half-way and about 5 drops of muriatic acid. Cap it. Shake the bottle for 2 minutes. When it settles, remove the top layer and throw it away. The free base has now been bonded to the HCl again, forming a water soluble salt. This time, we’re getting rid of ether-soluble impurities. Make sure to get rid of all the ether before going to step 11!
10. If there is anything left from step 3, repeat the procedure with it.
11. Evaporate the solution in the Pyrex dish on low heat. You can do this on the stove or nuke it in the microwave (be careful of splashing), but I have found that if you leave it on top of a hot-water heater (like the one that supplies hot water to your house) for about 2-3 days, the remaining crystals will be ephedrine HCl.
If you microwave it, I suggest no more than 5-10s at one time. If it starts «popping», that means you have too little liquid left to microwave. You can put it under a bright (100W) lamp instead. Microwaving can result in uneven heating, anyway.
Amphetamine FAQ
BigTrancer
Bluelight Crew
PREFACE:
This guide is intended to provide a comprehensive, unbiased source of information for all things related to the drug commonly called Speed. This is the first in a series of guides I hope to produce on drugs as a project I have undertaken to become a better informed individual.
The information in this guide is provided for educational purposes only. Please be aware that use of possession of amphetamines is restricted in most countries of the world. I won’t be held responsible if you get into trouble misusing this information.
Most sections have a Short Answer and a Long Answer. While the short answer will give you the gist of what you want to know, I encourage you to read the long answer and get the full picture.
Special thanx to BigTrancer for his editorial input, without which, this document would be a steaming pile of misinformation.
Comments or suggestions should be sent to renegade at theposse dot kicks-ass dot net.
LEGAL NOTICE:
This document is Copyright (C) 2003 Renegade. This document may be redistributed freely in its whole and unchanged form only. Please let me know if you intend to host this document locally so I can keep you informed about updates.
Long Answer:
‘Speed’ is the street name commonly used in reference to amphetamine(s), a psychomotor stimulant that affects the central nervous system. Amphetamine is the accepted pharmaceutical name for a specific drug (i.e., C9H13N as (+/-)-alpha-methylbenzenethanamine, or racemic 1-phenyl-2-aminopropane, see Merck Index Entry #623), while the plural amphetamines generally applies to a family of chemically related compounds with similar physiological effects. Amphetamine, dextroamphetamine, and methamphetamine are all types of amphetamines.
On the street, amphetamines go by many aliases, such as goey, wizz, speed, dex, crank, phet, tweak, yaba, and base. Methamphetamine is usually referred to simply as ‘meth’, ‘crystal meth’ or ‘ice’ (due to its appearance). This can be confusing however as ice is also a street name for the drug 4-methylaminorex (also known as 4-MAR or ‘shabu’, which is chemically unique from the amphetamines). Amphetamines are also sold in pharmacies by prescription in some countries, under various names such as Benzedrine (amphetamine), Dexedrine (dextroamphetamine), Methedrine, and Desoxyn (methamphetamine). Adderall (mixed amphetamine salts) and Ritalin (methylphenidate) are commonly prescribed medications that have amphetamine effects.
2. WHAT ARE ITS USES?
Short Answer:
Medically used to treat narcolepsy and attention deficit disorders (ADD). Recreationally used as a stimulant.
Long Answer:
In the past amphetamines have been prescribed by doctors for all manner of medical conditions, including weight loss, depression, schizophrenia, Parkinson’s disease, epilepsy, fatigue, narcolepsy and attention deficit disorder. At one stage it was believed there were up to 39 medicinal uses for amphetamines, however these days they are generally only prescribed for narcolepsy and ADD.
Recreationally amphetamines are used to provide a boost in energy levels and feelings of euphoria and happiness. They are often used by truck drivers, students and other ‘nocturnal’ occupations as a means of staying awake for extended periods of time. Amphetamines are more popular amongst people who engage in extended periods of physical exertion, such as athletes, and physical labourers.
3. WHAT FORMS DOES IT TAKE?
Short Answer:
Sold as pills by prescription in pharmacies. On the street usually a white or off white powder, sometimes a paste or rock.
* RED: The product was made from pseudoephedrine tablets, and the red colouring of the tablet was not adequately washed away (it is difficult).
* ORANGE: Ephedrine sulphate was used, and some of the sulphate was reduced to sulphur.
* PURPLE: Iodine from a phosphorus-iodine reaction was not washed out.
* GREEN: Copper (or other metallic) salts somehow made their way in to the mixture, probably due to the reaction vessel used in the manufacture.
* BROWN: Oxidized red colouring (see above), or tabulating agent was present in the reduction.
In many places, methamphetamine is more common than amphetamine, because it is more potent and easier to make. Pure methamphetamine is easily crystallised and is more readily smokeable than amphetamine because it doesn’t have to be converted to freebase first (since methamphetamine sublimes directly from solid to vapour form with the application of heat). Due to the size and appearance of the crystals, methamphetamine is often referred to as ‘crystal meth’, ‘ice’ or ‘glass’. While methamphetamine tends to have more pronounced effects than amphetamine, most things that are true for amphetamine also hold for methamphetamine.
Sometimes amphetamines are sold as a pasty or waxy substance. There are a few reasons this can happen; a common misconception is that pasty or damp amphetamine samples are ‘stronger’ than dry powder. Damp of pasty speed can result from leaving it out in the open, especially in a moisture rich environment, because certain chemicals absorb water from the air (explained below). Moreover, if all of the freebase is not properly reacted when converting to salt, the oil will cling to the crystals causing them to stick together in waxy clumps. Neither of these things makes the end-product any more potent than the dry salt (although freebase is more potent by weight than the salt form).
Chemically speaking, amphetamines are generally either a freebase or a salt. The term ‘freebase’ is widely misused in regards to amphetamines; used correctly, freebase refers to the drug in its natural (pure) form. Since amphetamines are amines, and amines are bases, the pure form is called the freebase because it is the base free of any other functional groups. Freebases tend to be oily liquids at room temperature and pressure, and are often quite volatile (i.e., they evaporate easily). As a consequence, the freebase form is generally preferable for smoking; however, freebase oils are also more difficult to store and measuring accurate doses can be problematic. For this reason the freebase is almost always converted to a salt.
The salt form is more common on the street, and is made by performing an acid/base extraction of the freebase, where the type of salt produced depends on the acid used. With most drugs, hydrochloric acid (HCl) is used, which produces HCl salt. However in the case of amphetamines, the HCl salt is not particularly suitable because it absorbs moisture from the air quickly (i.e., amphetamine HCl is ‘hygroscopic’). For this reason the sulphate salt is preferable to the hydrochloride salt; as a consequence, most ‘street speed’ is amphetamine sulphate. In the case of methamphetamine, the HCl salt is far more common, because it forms better crystals and the sulphate is not suitable for smoking.
Amphetamines are also sold in illicitly produced pills and often passed off as ecstasy, referred to as ‘speed bombs’. This is generally done for 2 reasons: 1) amphetamine is cheaper to make than ecstasy; 2) Some people prefer to take a pill because they perceive a pill as being ‘safer’ than a powder, or they don’t like snorting. (Note: methamphetamine tablets known as ‘yaba’ are common throughout Southeast Asian countries; these tablets are cheap, and quite strong, and are designed to be smoked rather than eaten like ecstasy).
It is also common practice for dealers to ‘cut’ their speed. This refers to mixing the speed with some other powder, usually a sugar of some kind like glucose, or a bitter agent such as Epsom salts. This makes the product go further when selling it but the diluted end-product and inflated prices are undesirable to many users.
4. HOW DO YOU IDENTIFY IT?
Short Answer:
You can’t reliably tell by appearance smell or taste, use a reagent tester to be sure.
Long Answer:
Street speed is most frequently a white powder. It has a very bitter taste, and is quite caustic. It has an acrid smell.
That said however, you cannot identify speed based on its appearance. Taste is also unreliable (and dangerous) because it may have been cut with glucose, which will just make it taste sweet, or something more dangerous and toxic. I find that speed does tend to have a very characteristic smell, but it can be difficult to discern and is still not as very reliable method. (note: the smell of speed can vary hugely from synthesis to synthesis, products with smells ranging through ‘paint thinner’, ‘dead ants’, ‘nail polish remover’, and other volatile organic chemical aromas are possible from improperly cleaned product).
5. HOW DO AMPHETAMINES WORK?
Short Answer:
Amphetamines stimulate the central nervous system and promote the activity of certain neurotransmitters in the brain.
Long Answer:
Simply, amphetamines work by stimulating the central nervous system (CNS). This stimulation leads to the acceleration of other bodily functions, which is what ultimately causes the effects of the drug. Loss of appetite is caused by increased metabolic rate, while increased blood pressure and temperature can result from an increase in heart rate.
6. HOW IS IT TAKEN?
Short Answer:
Basically, you can eat it, snort it, smoke it or inject it intravenously.
Long Answer:
Depending on the form its in, amphetamine can be taken in a number of ways, each having a different affect on the user:
ORALLY:
The simplest way is just to eat it. This can be done in a number of ways. Licking some from the end of a finger or car key is probably the easiest, but most unpleasant since speed tends to have a very bitter taste. It also tends to be quite caustic, so it can result in a chemical burn on the tongue (assuming pure amphetamine that hasn’t been cut back). More than likely the powder has been cut with something like glucose, and will have a slightly sweeter taste and be less caustic. Similar to this is ‘gumming’ it. This involves dabbing a bit on one’s finger and rubbing it above the teeth, around the gums; the blood vessels in the gums absorb some of the drug before it gets to the digestive system. This is more effective than other oral ingestion methods, but corrosive to the teeth and gums.
Another method is to dissolve the powder in water (it is a salt after all) and drink the water. Again, the taste is not pleasant, however a benefit of this ingestion method is that any non-soluble adulterants will sink to the bottom of the drinking vessel, allowing the user to avoid ingesting them. To avoid the taste of the speed altogether, some people prefer a method called ‘parachuting’ or ‘bombing’; the powder is wrapped up in a piece of tissue paper or a cigarette paper, and swallowed whole like a tablet. This way the powder arrives in the stomach at the same time, and the paper dissolves quickly, allowing the chemical to be absorbed at once. Another way to do this is to buy empty gel capsule from your local health food store and put the powder in one of these and swallow it.
The main advantage with oral administration is that it is quick and easy. There are however some fairly major drawbacks. Apart from the foul taste, taking speed orally is the most inefficient way. It takes the longest time to for the effects to come on, typically between 30-45 minutes, and your body will only absorb around half of the drug when taken this way. The reason for this is that the ingested chemical passes through the liver prior to entering the bloodstream, where enzymes metabolise some of the drug before it takes effect. The long onset often means the effects seem quite mild as opposed to the ‘rush’ obtained from other methods. This can lead to a careless user taking a much larger dose than necessary.
INTRANASALLY (or INSUFFLATION):
Probably the most common way to take speed when it is in a powder form is to ‘snort’ it. This is usually done by laying out the powder in a thin line (rail) or a small pile (bump) and snorting it through a tube. You can also buy ‘snuff bullets/rockets/snorters’ from some head shops, which is a device that looks like a large bullet and ejects a small (roughly measured) amount of the powder when the button on the bottom is pressed, allowing the device to be pushed up to a nostril and the small dose of powder to be snorted. The powder then gets caught in the nasal passage and the drug is absorbed directly into the blood stream through the mucous membranes.
The advantages of snorting speed over taking it orally are that it has a much quicker onset and higher rate of absorption. This is because the chemical is absorbed straight into the blood stream through the mucous membranes rather than passing through the liver first. The effects will come on in a matter of minutes and the onset is much more pronounced, giving the user a ‘rushing’ sensation. Usually more than about three-quarters of the drug is absorbed into the blood stream when snorted.
The disadvantages of snorting are mostly to do with the experience being rather unpleasant. Since amphetamines are corrosive, they can cause burning when lodged in the nasal passage. Because the mucous membranes are quite thin and delicate, this can lead to a bleeding nose. Not all of the speed will dissolve in the nose and be absorbed through the mucous membranes, and sometimes speed is cut with something that isn’t water-soluble, so you are going to end up with a lot of powder stuck up your nose. Whatever doesn’t dissolve eventually ends up ‘dripping’ down the throat and tastes very unpleasant. Any speed that wasn’t absorbed in the nose is then swallowed, and subject to first-pass metabolism in the liver before reaching the blood system as discussed above.
This brings us to the disadvantages. Again, the caustic nature of amphetamines turns out to be a pain in the arse (pun intended), when the cap finally dissolves you may feel some burning/discomfort and a need to go to the toilet (which is another reason it is preferable to go first). If you can resist, the discomfort should pass within 5-10 minutes. A further disadvantage is that you have to stick your finger into your rectum (at least as far as the second knuckle) to locate the capsule. One suggestion to make the insertion of the capsule slightly more hygienic is to put a condom on your finger. The other main disadvantage is that anything non-soluble is just going to come out again (sooner rather than later), so whatever you do DON’T FART before you go to the toilet.
INHALATION:
Inhalation of amphetamine is possible by heating the drug until it turns to vapour and inhaling the vapour. This is often referred to as smoking, but that is technically incorrect since you are not inhaling the products of combustion. Smoking has an almost instantaneous onset, giving a sudden rush of euphoria (more so for smoked methamphetamine). Most of the drug will be absorbed into the blood stream (the only part that won’t be is any vapour that dissipates before you inhale it), so the required dose is a fraction as much as required by other methods. This would then seemingly be the best method of administration but it does have some serious drawbacks.
The rush is short lived and the come down is pretty harsh, making it extremely habit-forming and physical and psychological dependence can result. Even though you really only need half as much this way, you frequently end up using twice as much. It is also quite harsh on the lungs (note: due to the solubility of amphetamines discussed above, these drugs do not ‘re-crystallise’ in the lungs when smoked; this is a common myth which seems to be brought up whenever smoking speed is discussed).
There is also an array of chemical related problems. You can’t smoke the sulphate salts, because the melting points are too high (around 300C), it the powder substance will actually combust before it releases an appreciable amount vaporised amphetamine. If you have amphetamine sulphate it must be converted to freebase before it can be smoked efficiently. Methamphetamine HCl is smokeable, because it sublimes into the freebase and HCl under application of heat. Methamphetamine is also easily re-crystallised to form ‘crystal meth’. Crystal is better for smoking because the powdered salt tends to burn easily, and is generally free of impurities because crystals only grow from pure substance. However it is possible for impurities to get trapped between crystals as they are forming. Purity of the drug is important when smoking because any impurities will require a much lower dosage to be toxic when smoked.
Freebase is more suited to smoking since it evaporates easily; however, since freebase is hard to come by, if you want to do it this way you will likely have to do the conversion from the salt yourself (for information on this see the CHEMISTRY section). Also, the boiling point for (meth)amphetamine freebase is about 203C, which can be difficult to produce with a normal cigarette lighter (use a jet lighter for best effect)
Injecting amphetamine gives the ‘best and fastest’ high, as all of the substance makes it straight into your blood stream. The rush experienced from IV is much stronger than from smoking but also less long lasting, making it even more habit-forming. Even the process of injecting can become habit-forming for some people.
The dangers, however, can far outweigh the benefits gained from injecting. In short, the use of hypodermic needles effectively bypasses every natural filtration system the body has, introducing a foreign substance to the blood system directly. Even injections carried out by trained practitioners in sterile situations, using pure pharmaceuticals, are not without risk; however in circumstances of questionable hygiene, untrained users, and black market drugs with no knowledge of purity this method of administration is extremely high risk. The addictiveness of the rush and the short duration of the high often mean that injecting users will use much more drug over time than other users. Those things aside there are still serious problems involved with injecting in general: the ease of catching a disease, the extra expense of needles, problems with purity of the drug.
I will not go into the details of injecting since there are many guides to safe injecting on the net already, and I personally do not see the need to inject anything which can just as easily be swallowed, snorted or smoked. I will say this though: if you must inject ALWAYS use fresh sterilized needles for EACH INJECTION, do NOT share needles EVER, and finally, when injecting anything it is VITALLY important that the substance be PURE. If you inject cutting agent or some other additive you greatly increase the risk of developing life-threatening health complications. Do not inject anything you haven’t made/tested the purity of yourself. For more information on this see the CHEMISTRY section.
Long Answer:
Onset of the drug will depend on the method of ingestion and the bodys metabolic rate where applicable. The numbers given below are only a guide (based on the experience of myself and people I know), and will vary from person to person:
The duration of the effects also depends largely on the method of ingestion, dosage, and the type of amphetamine taken. Other influencing factors include tolerance to the drug (developed through frequent and repetitive use) and body mass of the user. Assuming a single average dose (outlined below) of pure amphetamine for an infrequent user, I have given a rough guide below (regular users shouldn’t need any help with this section). Again these numbers will vary from person to person. Duration will be lengthened by re-dosing. Note that delayed absorption (e.g., orally) offers a more prolonged experience than via direct administration (e.g., IV).
8. WHAT IS THE REGULAR DOSE?
Short Answer:
Beginners should take less than 50mg intranasally or orally.
Medically, amphetamines are distributed in 5 and 10mg doses, with maximum recommended doses for most medical conditions rarely exceeding 30mg spread out over the course of 24 hours. People who take amphetamines for medical reasons like narcolepsy or ADD will feel less pronounced effects than someone who doesn’t, because the body builds up a tolerance.
So what is a good dose for a beginner? Well the first thing to keep in mind when trying something new is you can always have more but you cant have less, so start small and wait a while, if you don’t feel the effects then you can have a bit more. Take something less than 50mg of pure substance either snorted or swallowed for your first attempt (note: 50 milligrams is equal to half a ‘point’, which is a measure commonly used for illicit powders. One ‘point’ is equal to ‘point-one’ or a tenth of a gram (0.1g = 100mg). Smoking or injecting for your first time could be considered a bad idea for a couple of reasons: First, the sudden rush can be a bit overwhelming for someone who doesn’t know what to expect. Second, these methods are significantly more habit-forming.
One important thing to consider is that street speed is never going to be pure, and the purity will vary widely from one batch to another. Typically, the purity can be around 10-15% amphetamine, but sometimes as low as 2%; the rest is known as an ‘adulterant’, usually a cutting agent like glucose, Epsom salts or sometimes caffeine. Half a point of street speed is probably not going to have a much of an effect (this dilution by cutting is why ‘street speed’ is sometimes sold in ‘weights’ (grams) or ‘half-weights’ (0.5g = 500mg), whereas speed and methamphetamine of much higher purity can be obtained in measures a fraction the size (i.e., ‘points’) for a similar price), so a larger dosage will be required to have the desired affect. How much larger is impossible to determine without knowing the purity so the best idea is to ask the person you got it off how strong it is, and how much they would recommend for a beginner. If it’s your first time don’t take more than a point at once. Given time and experience you should be able to gauge what a decent dose for yourself. The key is to be sensible with it.
One last note, is that since methamphetamine tends to be more potent, you likely won’t need as much. The above guidelines can still apply to methamphetamine but it won’t hurt to take a bit less.
9. WHAT IS THE OVERDOSE LEVEL?
Short Answer:
Varies from person to person, but 50mg of pure amphetamine can be toxic for a non-tolerant user (note: this figure is for hypersensitive users, and since amphetamine is rarely encountered in a pure form, this is why the above section reads ‘less than 50mg’). Lethal dosage in rats is 55mg/kg taken orally (ref: Merck Index)
Long Answer:
Much like the recreational dose, the overdose level is difficult to pin point because of differences between people. Deaths have been reported at levels as low as 1.3mg/kg (i.e., at a dose level equivalent to 1.3 milligrams of amphetamine per kilogram of the users bodyweight; e.g., in a 80kg human this would equate to a dose of 104mg), other reports state tolerance has been built up to 1 gram at a time and up to 5g in a day without being toxic to the user. These extremes indicate the variation of overdose levels. People who are allergic to a component of the substance ingested (recall that these ‘drugs’ are powdered mixtures which may have significant adulterants due to lack of any quality control in the synthesis procedure and overzealous cutting) or anaemic people have a higher risk of overdose at very low levels, while people who are frequent users may be able to withstand a much higher dose. Because of the difficulty in determining the overdose level it is important to be sensible with your consumption and to know your own limits. It is also important to be able to identify the symptoms of an overdose.
Symptoms of acute overdose can include restlessness, rapid respiration/perspiration, confusion, tremor (the shakes), and nausea. Presence of these symptoms generally indicate only mild levels of toxicity and you should probably just lay off it for a while, drink some water and try to calm down.
Symptoms of high level overdose include vomiting, diarrhoea, abdominal cramps, hallucinations, panic attacks, paranoia and circulatory collapse. These symptoms are indicative of a much higher level of toxicity and occur from much larger doses. If you (or friends) experience these sorts of symptoms a doctor or paramedic should be contacted immediately (emergency). Fatal poisoning is usually preceded by muscular convulsion and coma.
LD50 is a term for the dosage required to kill 50% of the test subjects. According to the Merck Index, the LD50 for amphetamine in rats is 55mg/kg taken orally. There isn’t really any data specifically on the lethal dosage for humans since no formal testing can be done.
10. WHAT ARE THE PRIMARY EFFECTS?
Short Answer:
Increased energy levels and mental alertness. Often accompanied by feelings of euphoria and suppression of appetite.
Long Answer:
Amphetamines work by stimulating the CNS, which in turn speeds up bodily functions. It is the speeding up of bodily function that is responsible for the primary effects of the drug:
* Increased energy levels: caused by speeding up metabolism and heart rate, which means you have more energy to burn your blood is carrying the energy around your body.
* Increased mental awareness: caused by stimulated release of neurotransmitters.
* Sense of elation, increased self-confidence: amphetamines stimulate the dopamine system in the brain, causing amplified emotions and energy levels.
* Other noticeable effects include talkativeness, dry mouth, sweating, dilated pupils, rise in body temperature, and suppression of appetite.
* The ‘rush’ effect is caused by large amounts of the drug reaching the brain at once. The effect goes away once the drug dissipates in the blood stream.
11. WHAT ARE THE SIDE EFFECTS?
Short Answer:
The most common side effects include insomnia (inability to sleep), twitching, muscular soreness, increased aggression, inability to regulate body temperature and restlessness. At higher doses the side effects become more severe, including diarrhoea and psychosis.
There are more serious side effects but they generally are only associated with very high doses or overdoses. They include vomiting, diarrhoea, and psychosis. Amphetamine psychosis is a mental disorder with similar symptoms to schizophrenia, and is brought on by repetitive, high dose, prolonged use of amphetamines. It is caused by subtle hallucinations and changes in state of consciousness, which are difficult for the user to perceive. In some cases users may experience full-blown visual and auditory hallucination.
Then there is always the come down. ‘What goes up must come down’, as the saying goes. Coming down refers to the primary effects of the drug wearing off, in the case of amphetamines, the fading of any euphoric feelings and extra energy. The thing about coming down is that you rarely come down just back to your normal state. More often than not you travel a proportionate distance down the scale, as it were, before returning to normal. The result is that users often feel tired, lethargic and depressed or irritable on a come down. The effects of the comedown are more severe at higher doses, and as the drug dose is increased, the negative after-effects can be amplified far more than the increase in positive effects. A small to medium sized dose will most likely leave you feeling a little worn out. Staying awake for three days on speed will likely result in collapsing from exhaustion and a foul temper, followed by several days of ‘hangover’ type effects.
12. WHAT ARE THE LONG TERM EFFECTS?
Short Answer:
Anorexia and malnutrition, insomnia, skin disorders, depression, anxiety, psychosis, high blood pressure, stroke, neurotoxic damage.
Long Answer:
The most common side effect of long-term amphetamine use is insomnia. In some cases this may mean inability to sleep for more than a few hours at a time, in more server cases inability to sleep for days on end. Chronic fatigue syndrome and depression may follow as a result. Another common long-term effect is malnutrition or anorexia, which happens as a consequence of long-term appetite suppression.
Frequent higher doses can lead to hypertension (high blood pressure), and in some cases can increase the risk of a stroke. Amphetamine psychosis can also be caused by either long-term use or long periods spent under the influence of the drug.
There is some research that suggests extended amphetamine use may cause neurotoxic damage by constant over stimulation of dopamine receptors in the brain (ref: see bibliography for details.) Most of the effects of long-term amphetamine use are believed to fade within 4 months after last use of the drug, meaning that the drug has few lasting permanent effects. The possible exception to this is reversal of neurotoxic damage. It is believed that while some recovery is made, not all neurotoxic damage heals. (Note: excessive use of amphetamines over long periods can cause damage to the teeth and gums, particularly when ‘gumming’ powdered street speed. This damage is not reversible, as the tooth enamel can be pitted and the gums can retract).
13. WHAT ARE THE DANGERS?
Short Answer:
Addiction, disease (from sharing needles, etc), overdosing, death, amphetamine psychosis, possible long-term neurotoxic damage.
Long Answer:
Aside from the all the side effects outlined above, there are numerous other dangers associated with amphetamine use. Addiction is probably the most prevalent. While speed may not seem like a particularly habit-forming drug, because dopamine is replenished so efficiently by the body, it is easy to taking speed every day without instantly noticing the effect of tolerance (this compares, for example, with MDMA pills which have rapidly diminishing returns on the second and third days). What starts out as a little ‘pick me up’ in the morning can quickly turn into half-gram-a-day habit, because tolerance to the drug builds quickly. Once you start using every day it will almost certainly be a monster effort to stop. This compounded by the exponentially harsh comedowns associated with taking a break after frequent use. People have been unable to get out of bed for days after a speed binge.
The other big danger I have mentioned briefly above is the risk of getting bad quality product. Amphetamines more than most other drugs are prone to impurities and tampering. This stems from the fact that amphetamines are quite easy to make, and the majority of street amphetamines are manufactured in clandestine laboratories. Inexperienced and uneducated chemists frequently leave impurities in their finished product because they either don’t know how to detect them or how to separate them out (furthermore, properly drying and cleaning the end-product reduces the overall mass of substance, and therefore the profit). Some chemists will even add other, often toxic chemicals to the mix to make it seem more potent. The other problem is that amphetamines are often cut back with sugars and salts and other things to make the powder go further, enabling dodgy dealers to sell 5 grams of active content as 10 grams for twice the profit. Since many users haven’t the knowledge or the time to test purity, this almost an accepted consequence of being a speed user.
Lastly, while it is rare that someone dies directly as a result of amphetamine overdose, death can also result from amphetamine induced strokes, or even self injury while suffering a psychotic episode. People with heart conditions should avoid taking amphetamines. It can also harm a developing baby while pregnant or transfer through breast milk. NEVER use un-prescribed drugs while there is a chance of pregnancy.
14. WHAT SHOULDN’T IT BE COMBINED WITH?
Short Answer:
You should avoid taking amphetamines if you are on MAOI medication. Taking it combination with cold remedies is dangerous because they frequently contain chemicals similar to amphetamines which when combined can raise the blood pressure to dangerous levels.
Long Answer:
Taking amphetamines while using a Monoamine Oxidase Inhibitor (MAOI) can lead to dopamine poisoning in the brain. This is because MAO is the enzyme which breaks down dopamine, and taking amphetamine causes high levels of dopamine to be released into the brain.
Also, there has been research to link the combination of amphetamine and MDMA (ecstasy) with increased serotonogenic neurotoxic damage. The theory behind this is that the excess dopamine from taking amphetamine enters into serotonin cells once the serotonin is depleted, and dopamine is toxic to serotonin cells. This research is somewhat dated however, current opinion seems to be that neurotoxic damage caused by taking ecstasy is mostly related to increased body temperature.
Another thing to note is that taking amphetamines with other stimulants can be dangerous because it can lead to excessively high blood pressure and dangerous increases in body temperatire.
Finally, taking amphetamine with GHB/1,4B or other depressants can be dangerous as well. Use of amphetamine allows a much higher dose of GHB to be taken, but if the amphetamine wears off first, loss of consciousness and repertory functions may result. Or if the GHB wears off first, over stimulation can occur.
15. HOW LONG DOES IT STAY IN YOUR BODY FOR?
Short Answer:
It is difficult to detect metabolites of speed using standard (e.g., NIDA-5) blood or urine tests after approximately 48 hours.
0.02% of the original dose is left in your body. Accordingly, larger doses will take longer to reach undetectable amounts, but after 72 hours the level of metabolites in the blood or urine should be below detectable concentrations.
16. LEGAL ISSUES
The legalities of amphetamine production, possession and use will vary depending on what country (and usually state) you are in.
The United Nations has various Conventions on how member counties should deal with illicit drugs. Amphetamines are regulated as directed by Schedule II of the United Nations Convention on Psychotropic Substances 1971. The Convention is an international treaty that sets out a list of rules on the way participating countries control the substances listed in its 4 schedules. The full text of the Convention is available at http://www.incb.org/e/conv/1971/, but I have quoted a few of the important bits from the Article section below:
This basically says you cannot make it without a licence and you cannot possess it without a prescription, and that if those controls aren’t tight enough the government can implement tighter controls as it sees fit.
The United Nations Convention Against Illicit Traffic In Narcotic Drugs And Psychotropic Substances 1988 outlines in more detail how the legislation of participating countries should be written. Probably the most important thing to note is:
The full text of the convention is available at http://www.incb.org/e/conv/1988/
The specific laws which implement these rules vary from country to country. In Australia the relevant pieces of legislation are the PSYCHOTROPIC SUBSTANCES ACT 1976 and CRIMES (TRAFFIC IN NARCOTIC DRUGS AND PSYCHOTROPIC SUBSTANCES) ACT 1990 respectively.
Amphetamine belongs to the family of chemicals known as phenethylamines. A phenethylamine is the combination of functional groups phenyl (-C6H5), ethyl (-C2H5) and amine (-NH2).
The phenyl (benzyl) group is 6 carbon atoms bonded together in a hexagonal ring structure, in which each carbon can be thought of as being held in place by a double-bond on one side and a single-bond on the other (this simplification is explained in any organic chemistry textbook). Each carbon acts as a place for another functional group to bond to, in this case one carbon in the ring bonds to an ethyl group, and the other five carbons are saturated with hydrogen atoms.
An ethyl group (Et) is essentially two carbon atoms singly bonded together. One has two hydrogen atoms bonded to it and the other has three. The first carbon is bonded to the phenyl group in place of the 3rd hydrogen.
An amine group is a nitrogen atom singly bonded to 2 hydrogen atoms, which has room for one more bond. If you take away the 3rd hydrogen from the ethyl group previously mentioned and bond the amine to it there, you have a phenethylamine.
Amphetamine is actually a shortened version of the full chemical name dl-Alpha-MethylPHenEThylAMINE. It is one of the simplest variations to the basic phenethylamine molecule. A methyl group (-CH3) is bonded to the 2nd carbon in the ethyl group in place of one of the hydrogen atoms.
The molecule has the chemical formula C9H13N and is structurally represented as:
Methamphetamine is a simple variation, where a second methyl group is singly bonded to the amine in place of one the remaining hydrogen atoms.
18. HOW IS IT MADE?
Synthesis of amphetamines is a relatively simple process, assuming you have access to the right precursors and equipment, and a decent understanding of chemistry. Interestingly, it is actually easier to make methamphetamine than regular amphetamine (at least using clandestine methods), which is largely responsible for its popularity on the street in certain countries. There are many commonly used methods of synthesis, the most popular of which is probably the reduction of (psuedo)ephedrine using Hydroiodic Acid and Red Phosphorous (HI/RP reduction). Amphetamine can be made by further reducing methamphetamine to lose its second methyl group but most people would consider this a waste of good meth. The most popular method for synthesis of amphetamine is reductive amination of Phenyl-2-Propanone (P2P). The use of this method is also a bit puzzling because methamphetamine can also be made from P2P using the same reaction with different reagents.
The exact details of these reactions are beyond the scope of this document, mostly since there is already a wealth of good information on Rhodium. Please keep in mind that amphetamines are controlled substances in most countries and synthesis of such could land you in serious trouble. Furthermore, possession of information detailing how to synthesise methamphetamines (with or without the glassware or reagents) may be illegal in certain jurisdictions.
19. HOW CAN I PURIFY MY SPEED?
There are a few different methods for purifying amphetamine, but one of the simplest and best ways to do this is with a dual solvent re-crystallisation. If you plan to do this however, be prepared for a LARGE reduction in volume. Keep in mind however the stuff you separate out isn’t really any good to you anyway. Consider the fact that most street speed is less than 15% pure, which means the gram you just bought has about less than 150mg of active content. If done extremely carefully you won’t lose much of the actual speed.
Re-crystallisation is based on the different saturation levels of hot and cold solvent. A saturated solution is one which has the maximum amount of solute dissolved in it. The saturation level of any given solvent rises and falls with the temperature. Put simply, when a solvent is heated it can dissolve a larger volume of solute, and as it cools and the saturation level drops, excess solute will form into crystals and sink to the bottom.
A simple purification can be done using a single solvent. Add hot solvent to the amphetamine in small amounts until it is all dissolved. Anything that will not dissolve is adulterant and should be filtered out using coffee filters or filter paper (mositen filters first to prevent them soaking up solution). Next, allow the solution to cool slowly to room temperature, then place it in the fridge and allow it to cool further. Once it has cooled in the fridge filter the crystals out and allow them to dry.
It is worth noting that some adulterant may also be soluble and form its own crystals in the process, so what you have at the end may not necessarily be pure amphetamine. This is why a dual solvent re-crystallisation is preferred.
A dual solvent re-crystallisation works by using a second solvent to dissolve many of the impurities, but that the drug itself is not soluble in. The second solvent also acts as a cleaning agent for the new crystals being formed.
In the case of amphetamines the 2 best liquids to use are acetone and alcohol. Acetone is a component of paint thinner (and nail polish remover) and can be bought from hardware stores or art supply stores. Alcohol can be obtained from hardware stores or liquor stores. Acetone is used as the ‘mother’ liquid, amphetamine is insoluble in acetone but most of the crap used to cut it is.
20. HOW CAN I TURN SALT INTO FREEBASE?
Salts are the reaction of an acid and a base, so converting the salt back to freebase requires the reversing of the initial reaction, this is called an acid/base extraction. It’s a fairly simple process for someone with a decent understanding of chemistry and the right equipment. There is a wealth of information online about how to do A/B extractions and any decent chemistry textbook will cover it so I won’t go into too much detail here. Before attempting an A/B you should probably purify the drug first as described above.
The basic procedure involves basifying the speed with lye (sodium hydroxide/caustic soda). This is done by dissolving the speed in distilled water and mixing this with a solution of distilled water saturated with lye. This reduces the amphetamine to its freebase form which should separate from the water once it settles because it is not water soluble.
Amphetamine was first synthesised in 1887 by German chemist L. Edeleano. Originally he named it phenylisopropylamine. Methamphetamine was first synthesised in 1919 by Japanese scientist A. Ogata. However, it wasn’t until the 1920’s that physicians began to investigate medicinal uses for amphetamines. Around 1927 it was discovered to dilate nasal and bronchial passages, elevate blood pressure and stimulate the central nervous system.
In 1932 amphetamines debuted on the pharmaceutical market in the form of the Benzedrine inhaler, produced by Smith, Kline & French. It was sold as a treatment for nasal congestion to asthmatics and people with colds.
In 1935 it was successfully used as a treatment for narcolepsy, a medical disorder characterized by sudden and overwhelming feelings of sleepiness and fatigue.
In 1937 it was found to improve concentration and mental performance in people suffering from ADD (or ADHD: attention deficit hyperactivity disorder). Amphetamines were approved for sale in tablet form in 1937, by the American Medical Association. It was sold by prescription as a treatment for ADD and narcolepsy.
During World War 2 (1939-1945) amphetamine use rose rapidly, as soldiers on all sides were given tablets to help keep them awake and alert for extended periods of time. This lead to an epidemic of amphetamine use in Japan that continued throughout the 1950s.
In 1940 methamphetamine became available in tablet form, sold as Methedrine by Burroughs Wellcome. By 1942, both methamphetamine and dextro-amphetamine were widely available over the counter without a prescription, and were aggressively marketed by manufacturers as a treatment for a range of ailments from weight loss and depression, to epilepsy, Parkinson’s disease, and asthma.
In 1956, amphetamines were restricted from being sold without a prescription in the UK. Despite this, non-medical use of amphetamines boomed amongst the general population throughout the 50s and 60s. ‘Pep pills’ were taken by bored housewives and students started combining them with barbiturates in a concoction called ‘purple hearts’.
Towards the end of the 60’s, physicians began to seriously question the medical value of amphetamines, as the hype surrounding non-medical abuse of the drug heightened. Many believed that doctors were too quick to prescribe the drug for just about anything without fully understanding its effects.
In 1970, the Comprehensive Drug Abuse Prevention and Control Act was passed in the US, which defined a scheduling system for drugs. Injectable methamphetamine was placed in schedule II, while other amphetamines were placed in schedule III. Shortly afterwards in 1971, all amphetamines are placed in schedule II (note: the lower numbered schedules represent more tightly regulated drugs).
By the 1980’s clandestine speed laboratories had become the greatest source of illicit amphetamines sold throughout the world (by FAR). Prices fell as speed became readily available on the street. Smoking amphetamines became popular, and amphetamine use continues to maintain popularity among the young people of society.
Fast forward to present day, nothing much has changed. Governments around the world struggle to curb amphetamine use, despite the ‘War on Drugs’ measures such as tighter controls on precursor chemicals (and glassware) vital to amphetamine synthesis, and ludicrously high penalties for manufacture or possession.
Like it or not, amphetamines are here to stay. Better to be informed than die from ignorance.
Much of the information in this document was sourced from a few key websites:
In addiction to those excellent sites, I have sourced information from a few other sites as outlined below. I may have forgotten to paste a few links as I was working so this list may not be exhaustive. Most of the information was found using Google.
Amphetamine how to make
1. Do some nitroethane
Nitroethane from Sodium Ethyl Sulfate [4]
1.5 mole sodium nitrite (103.5g) is intimately mixed with 1 mole of sodium ethyl sulfate (158g) and 0.0625 moles of K2CO3 (8.6g). The mixture is then heated to 125-130°C, at which temperature the nitroethane distills over as soon as it is formed. The heating is discontinued when the distillation flow slackens considerably, and the crude nitroethane is washed with an equal amount of water, dried over CaCl2, and if needed, decolorized with a little activated carbon. The nitromethane is then re-distilled, collecting the fraction between 114-116°C. Yield 46% of theory.
Preparation of Sodium Ethyl Sulfate
Method 1 [1]
To prepare the sodium salt of ethyl hydrogen sulfate, a mixture of alcohol and H2SO4 is boiled under reflux, cooled, and an excess of calcium carbonate is added. The ethyl hydrogen sulfate is converted into the soluble calcium ethyl sulfate, whilst the excess of H2SO4 is removed as insoluble calcium sulfate. The aqueous filtrate is then mixed with just sufficient sodium carbonate to give sodium ethyl sulfate, the insoluble calcium carbonate being now filtered off. The solution of sodium ethyl sulfate can be concentrated on the water-bath without appreciable hydrolysis, and the sulfate finally crystallized out.
Place 40ml (32g) of rectified spirit in a 250ml round-bottomed flask, and slowly add. 16ml (30g) of concentrated sulfuric acid, keeping the liquid in the flask well shaken throughout the addition to ensure thorough mixing. Fit a reflux condenser to the flask, and heat the latter on a gauze so that the mixture boils gently for 45 minutes. Then cool the product and pour it into 200ml of cold water contained in a large (8-inch) evaporating-basin or in a shallow earthenware dish. Now add 23g of finely powdered calcium carbonate with stirring to the acid solution. It is essential to add the calcium carbonate as a fine stream of powder, and to stir the latter immediately into the bulk of the solution: for this purpose, it is best to sift the carbonate through a fine sieve directly into the liquid, or alternatively to add it from a spatula, tapping the latter gently over the liquid to ensure steady addition of the finely powdered chalk. If the carbonate is added carelessly several grams at a time, it becomes rapidly covered with insoluble calcium sulfate, which protects it from further reaction: in these circumstances, at least 10 times the theoretical quantity of the carbonate may be required and the evolution of carbon dioxide may continue for several hours. The addition of the calcium carbonate should take about 30 minutes, and the well-stirred mixture should finally be neutral to litmus-paper. Now heat the mixture on a water-bath, using a thermometer as a stirrer, until the temperature reaches 60°C, and then filter at the pump through a wide Buchner funnel: at this temperature, filtration should be rapid. Finally wash the residue of calcium sulfate on the filter with a small quantity of hot water, adding the wash-water to the main filtrate. In order to convert the calcium ethyl sulfate to sodium ethyl sulfate, add a concentrated aqueous solution of sodium carbonate cautiously drop by drop to the well-stirred filtrate until a drop of the latter withdrawn on a glass rod is just sufficiently alkaline to turn red litmus-paper blue. Then filter the solution at the pump, and wash the residual calcium carbonate again with a small quantity of water. Evaporate the filtrate on a water-bath until a drop withdrawn on a rod crystallizes on cooling: then allow the solution to stand until almost cold, and finally chill it thoroughly in ice-water. (If the ice-water cooling is omitted, large well-developed colorless crystals of sodium ethyl sulfate will finally separate.) Filter off the crystals at the pump, drain, and dry over calcium chloride in a desiccator. Yield about 12g. To obtain a second (but necessarily less pure) crop of the sulfate, evaporate the filtrate further on the water-bath, and cool as before.
Method 2 [4]
Two moles of absolute ethanol (92 grams) is slowly dripped into a beaker containing one mole of 20% Oleum (H2SO4 containing 20% SO3), adjusting the rate so that the temperature is maintained at 45°C. When all the ethanol is added, the solution is neutralized with anhydrous sodium carbonate (Na2CO3), care being taken for the evolution of carbon dioxide. Yield 85% of theory.
2. DO SOME Phenyl-2-Nitropropene
[ Back to the Chemistry Archive ]
Procedure (By Dreamer)
To 55 g (0.5mol) Benzaldehyde in a 500ml Flask were added 40 g (0.5mol) Nitroethane and 10ml Cyclohexylamine. All was refluxed for 6h on a water bath. The result were 2 layers. One orange layer at the bottom with phenyl-2-nitropropene and a clear layer at the top with cyclohexylamine and maybe a little bit (
1ml) of H20. 50ml of H2O were added and then sucked off with a pipette until the phenyl-2-nitro-propene crystallized (it crystallized when it came in touch with air in presence of 15ml H2O). I added 200ml 95% denaturated ethanol to the orange crystals. The color of the now needle-like crystals changed from orange to white-yellow. The crystals were filtered. Yield 65 g, 78% of theory.
(YOU CAN EXCHANGE THE CATALYSATOR CYKLOHEXYLAMINE AGAINST AMMONIUM ACETATE..)
First of all many thanks go to CHEM_GUY for his continuous urging of the Hive
community to try Urushibara Nickel reduction on phenylnitropene. This reduction
turned out to be easier than any so far encountered. This is not based on any of
the excellent references pertaining to Urushibara that have been mentioned on
the hive, only chem_guys postings!
At the end of Al addition all green color from nickel salt should be discharged.
If any color remains add another gram of aluminum and wait for soln to clear.
Precipitated Nickel powder was added to 100ml 20% NaOH soln and manually stirred
at 60’C for 30 min. Excess NaOH is decanted and nickel is washed with 5 x100ml
aliquots of distilled water to remove excess base. At this point Urishubara
nickel catalyst is prepared and ready for reduction.
Dissolve 5g pure phenylnitropropene in 50ml Ethanol and add to Ni solution [2].
Now slowly add 3ml conc. HCl [3] and 1 gram shredded aluminum w/ manual
stirring. Aluminum will slowly dissolve with a more vigorous effervescence of
hydrogen than the first step. Maintaining good stirring with a glass stirring
rod is essential in beginning. Attempted magnetic stirring will result in
frustration because nickel is ferromagnetic and will stick to stirbar preventing
surface area exposure necessary for reduction. After aluminum is dissolved add
three more milliliters HCl and one more gram Al. Repeat adding acid and Al until
10 grams Al and about 30ml HCl has been added. Aluminum reacts slowly. Expect
addition to take about six hours, longer if temp falls below 50’C. Constant
stirring towards end is not necessary, just give mix a good stir occasionally.
After all aluminum is added and mostly decomposed slowly pour in a soln of 30g
NaOH in 100ml H20 with careful stirring. Wear goggles and be careful! Base
neutralization is highly exothermic! In 30 minutes all aluminum sludge will
solvate into bottom aqueous layer and a nice orange alcohol layer reeking of
amine will settle out on top. Nickel is not dissolved by the NaOH so it will
remain floating around between the two layers but this does not present a major
problem. After all, it’s not poisonous like mercury or anything! Now decant off
the top orange organic layer and distill off alcohol down to a orange stinky
syrup completely different smelling than the P2NP. Dissolve these goodies in
acetone and slowly add sulfuric acid to precipitate the amine sulfate.
Voila. about 3 grams light yellow amphetamine sulfate.
[1] Addition of water and acid found to be necessary to initiate rxn between
NiCl2 and Al.
[2] When nitropropene was added to NiCl2 soln before conversion to Ni powder
was complete some polymerization occurred greatly reducing yield.
It seems essential to add P2NP to rxn after Ni is fully precipitated.
[3] Use of Sulfuric acid produced inferior results causing polymerization of
P2NP to red tar.
Increasing Yield: Use overhead mechanical stirring to keep nickel catalyst
better suspended during reduction. Re-extract aqueous NaOH/Al
layer w/ toluene and work up in standard manner. Use larger
amount of nickel catalyst and more aluminum for H2 generation.
Why does everybody enjoy reposting what is already documented? What good purpose does this serve?
1.You took this from Rhodium’s site, meaning the links and a short description would suffice just dandy.
2.Much of the information on Rhodium’s site was taken from Hive discussions! This info is already here! Why repost it?
It is a waste. Links to Rhodium’s site with a description of what you are talking about, and post numbers relevant to the topic are all you need. You do not need to repost the entire writeup.
As a side-note, I could not agree more, unless someone has a source of PPA, which is easier to make into amphetamine than this of course. This process is my absolute number one favorite idea for producing amphetamine from scratch.
PrimoPyro
Vivent Longtemps La Ruche!
( Hive Bee )
03-15-02 20:25
No 283047
All the texts and methods at Rhodiums are difficult to orientate in, specially for newbees and persons without chemisty education.
Many methods which are high yeilding use exotic chemicals and expensive to obtain equipment..
Now when some newbee asks «How do I do amphetamine at home the easiest way», you can link this post..
1.The phenyl-alkyl group, that is attached to the N-piperidine structure.
2.The piperidine structure.
3.The anilino structure attached to the 4-piperidine.
4.The propionamide portion of the anilino.
Normally, the first portion is a phenethyl group. There are multiple ways of making the second level precursor: the phenyl-alkyl-piperidone. One way involves chaining the phenylalkyl bromide with piperidone.
Another way uses the phenylalkylamine, and constructs the piperidone ring around it. Phenethylamine would be used in this method as the amine, giving rise to phentanyl. If amphetamine were used, it would give rise to beta-methyl fentanyl I believe it is called by Drone 342, which may not be any more potent, but certainly lasts longer, like all amphetamine versions of phenethylamine drugs.
beta-methyl-3-methylfentanyl would be the strongest opioid I know of, with a dosage of a mere 60mcg for a 220lb (100kg) man, i.v. and it would last longer than the phenethyl version.
Sounds better than meth, no?
Rhodium: I make this assumption to cover my ass. I too think the amphetamine will have higher potency, but I have not read specifically so, so I stay with what I know for certain: amphetamines have longer action than phenethylamines, fentanyls included.
Obia: the stigma is the same the same the same. We’re not talking about fentanyl being perfect, but the bottom line is that it is here here and now, not hidden in some future discovery. Its not perfect by any means, but the stigma around it is severely overrated.
Every time a fentanyl discussion arises, the only information to surface is warnings about disaster, etc. Never any real chemistry discussions. All questions are answered with, «Do something simpler first.» and all topics on it are altered with negativity about its use.
I personally think this is because people dont have the answers to the questions, so they say what they know. They have heard these stories before, and heard others say its bad its bad its bad, its so dangerous, you’ll kill yourself, be careful, you’re not ready, try methadone, etc.
Obia, this most certainly not directed toward you. You have presented the data initially in the thread, which is good for first time readers, so dont think Im chewing you out, because Im not.
I think its about time for a new, good, fentanyl discussion. I wish Drone were here. He wouldnt listen to the «its dangerous, wha wha wha» bullshit either. All drugs are dangerous. End of story. Fentanyl has special conditions. Work in a glovebox.
Back to a useful discussion: Rhodium, in Post 60132 (Rhodium: «N-phenylethyl-4-piperidones via acrylates», Chemistry Discourse) you say that condensing phenethylamine with two equivalents of methyl methacrylate will give rise to 3-methyl piperidone. I assume this is a typo? Did you mean condense with one equivalent of the methyl methacrylate, and one equivalent of methyl acrylate? Would not two methyl methacrylate additions yield the 3,5-dimethyl-piperidone?
PrimoPyro
Vivent Longtemps La Ruche!
( Hive Addict )
03-17-02 02:30
No 283654
A discussion where I could have learned something suddenly changes to «the dangers of fentanyl» and the thread dies of its own accord. Yes, that really pisses me off. Its like being beaten in the head with «Drugs are bad, mkay?»
Dont back out of a discussion if you have something to say. I certainly dont have any equipment to test these things, but I dont mind talking about them.
PrimoPyro
Vivent Longtemps La Ruche!
( Chief Bee )
03-17-02 02:45
No 283661
Your correction of my post regarding the michael addition is fully correct, and I have changed my original post to reflect this.
( Hive Prodigy )
03-17-02 03:07
No 283670
«For oxalate salt (carfentanyl) ED50 = 0.0006 mg/kg i/v, this mean that for 100-kg body you need only 0.06 mg. FYI, for 3-methylfentanyl (ED50=0.00058 mg/kg i.v.) look up is synthesis in J. Med. Chem. vol 17, No. 10, p. 1047 (1974).»
This is from your carfentanyl synthesis paper on your site. 3-methyl fentanyl is stated to have an effective dose of 0.06mg, which is of course 60mcg.
It is only logical that the even more powerful amphetamine analog would be at least that potent as well, as well as my assumption of longer activity. I had meant to imply that it should be at least as potent as 3-methylfentanyl, the dosage of which I got from your site.
Rhodium, I wonder, is the activity of the 3,5-dimethyl-fentanyl less, or what is up with that? It would most certainly be easier to only have to use methyl methacrylate instead of methyl acrylate and methyl methacrylate. The methacrylate would produce the 3,5-dimethyl analog if it worked.
Also, would the methyl interfere with the michael addition? Doesn’t the carboxyl end up in the 5 position, or is it the 2/6 position?
PrimoPyro
Vivent Longtemps La Ruche!
( Chief Bee )
03-17-02 03:45
No 283689
( Hive Bee )
03-19-02 08:43
No 284704
(Rated as: excellent)
Also, when considering the potency of 3-Methylfentanyl, you have to consider that when you make it, you actually have four isomers, and only one of those posesses the extreme potency.
The t-Bu ester of beta-Alanine would be the starting amine for the Michael Addition with methyl acrylate.
And for the other way, the condensation of the bromo compound with piperidone, one would need either 3-bromopropionic acid, or the t-Bu ester thereof.
Could one dehydrate 3-bromopropionic acid and t-butanol with KHSO4 or something similar, to the ester? Will the bromine interfere?
Interestingly enough, the U.S.Army holds multiple patents on the synthesis of Carfentanil. It seems as though they had quite an interest in it around the late 70’s through the 80’s, perhaps for use as a chemical warfare agent?
( Chief Bee )
03-21-02 07:31
No 285741
I think I got the ED50 those compounds wrong. I don’t have the paper at the same location as the computer, so I’m just going from memory.
( Distinctive Doe )
03-24-02 19:45
No 287350
My thoughts were more along the lines of how in the hell could you ever safely disperse such a substance. Don’t know if i could trust any technique. At least if I was the one doing it. Blotters I guess, but I am skeptical of that.
I wonder what kind of quality controls they put on the fentanyl dispensaries? Hmmm Six-Sigma just don’t seem good enough to me. Maybee if all your errors were on the low side.
How do they accurately make blotters?
Every picture in my mind is of drops, uneven coverage and other shit messing it all up.
Those who give up essential liberties for temporary safety deserve neither liberty nor safety
( Hive Bee )
03-25-02 14:46
No 287623
But yes, they are the same.
PrimoPyro
Vivent Longtemps La Ruche!
( Chief Bee )
03-26-02 00:37
No 287814
( Distinctive Doe )
03-26-02 08:03
No 287983
Sure that sounds all well and fine for something like LSD, since it ain’t going to kiil anybody.
Think about paper chromatography, if you don’t apply the liquid nice and evenly then it seems lhighly likely that HOT spots would form. With such potent deadly substances it seems like a gamble. Maybee using multichannel pipettes to apply it, that would bee best. Hell YEA, buy one of those automated pipette machines that can load a 96 well plate all at once, then adapt it to loading 96 hit sheets.
Shit one person could cover the opiate supply for the WHOLE WORLD if they had that going. Imagine THAT.
Those who give up essential liberties for temporary safety deserve neither liberty nor safety
( Chief Bee )
03-26-02 08:39
No 287998
To avoid «hotspots» being detrimental to the user, do not make the blotter dosage so high that there is any health risk until a whole blotter sheet is ingested at once. As far as I know, carfentanil has such a large therapeutic window that 100x (a whole sheet) the active dose for a non-tolerant subject still is not lethal (don’t quote me on this).
( Old P2P Cook )
03-26-02 20:54
No 288183
My question is which if any of these fentanyls give the desirable heroin like high. Just look in PIHKAL and TIHKAL at the very different highs and effects from variations in the amphetamines, phenethylamines and tryptamines. I would imagine that these synthetic opiods also have a wide spectrum of highs and effects.
( Hive Bee )
03-27-02 06:22
No 288409
(Rated as: excellent)
Basically, it comes down to receptor binding. The binding effects at the µ-Opioid receptor are much different than the 5-HT2A receptor. And the effects that the agonists of these receptors manifest are completely different. While these are both G-protein coupled receptors, there is much more of a physiological response from opioid agonists, whereas the Serotonin agonists exhibit a psycological response, which allows much more room for interpetation.
( Chief Bee )
03-27-02 14:20
No 288524
What I want to know with this question is what receptor-binding profile would one look for in the pharmacological literature to find potential candidates for the effects one desires?
Are the receptors inter-regulatory, i.e. is it a difference between taking a mixed mu/delta agonist compared to two separate selective mu and delta agonists, provided that the binding is made just as strong by titrating the different dosages?
( Hive Bee )
03-27-02 19:04
No 288582
You’ve gotta love me.
( Hive Bee )
03-27-02 19:11
No 288584
(Rated as: excellent)
For our purposes, there are a select few receptors that we are looking to target, namely the µ-Opioid, 5-HT2A, CB1 Cannabinoid, Etc. This is, of course, not meant to imply that the other receptor subtypes are without merit, just that for what we are looking for (= fun compounds), they’re just not the place to be.
I just came across an interesting compound. N-(4-Bromobenzyl)-5-Methoxytryptamine. Apperently it is a very potent and selective ligand for the 5-HT2A receptors (Ki= 0.1nM) It was reported by Glennon et al: «Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalklamines.» J. Med. Chem. 1994 37 1929.
This could very easily be made from 5-Methoxytryptamine (which could be made from melatonin) by reacting with 4-Bromobenzylchloride in CH2Cl2 catalysed by DMAP or Hьnig’s Base (DIPEA).
( Hive Bee )
03-27-02 23:09
No 288678
flipper
Hive Bee)
03-27-02 19:04
Post 288582 (flipper: «question», Methods Discourse)
When I make a list of of all the chemicals used to synthesize carfetanil and fentanil ( maybe I didn’t spelled it ride but whatever) It’s a huge list. Can I shorten this list by say uing only MeOH or EtOH as solvent or use only one kind of dryingagent, without affecting the yield.
To answer your question, no. There are times for alcohol, and there are times for aprotic solvents.
( Chief Bee )
03-28-02 00:56
No 288738
( Master Whacker )
03-28-02 02:18
No 288766
(Rated as: excellent)
Check this paper out: J. Med. Chem. 2002, 45, 537-540
This paper is excellent, has info on some really cool oxycodone congeners with VERY high kappa and delta receptor affinity and little mu agonistic activity. There is also an analogue with extremely high Mu affinity, it is an adduct of B-nitrostyrene(isn’t that cool!) and N-Benzylimino-oxyxocone. It’s a simple procedure with a decent yield.
As you can tell, these are all experimental probes for neuroscience research. A delta or kappa agonist would never be commercialized, at least not as an analgesic, because they just don’t posses those properties. Many opiates on the market posses delta and kappa agonizing properties, but that is just peripheral to the µ action.
There is also one more opioid receptor, the Orphan Opioid Receptor ORL1 (Opioid Receptor-Like1) that has a high degree of homology with the mu, delta, and kappa receptors, but a distinctly different pharmacological profile. i.e., it looks and acts like the other opioid receptors, but doesn’t produce any effetcs that would normally be attributed to that family other than adenylyl cyclase inhibition.
I have ingested a selective kappa agonist before, and the only effects it seemed to produce was a slight headache and nausea.
( Hive Bee )
03-28-02 07:34
No 288873
crazyredhead
03-25-02 23:01
Post 287764 (crazyredhead: «Massive Renovation In Newbee Forum», Newbee Forum)
Massive Renovation In Newbee Forum
You’ve gotta love me.
( Hive Bee )
03-28-02 18:35
No 289076
slappy
(Hive Bee)
03-28-02 00:03
Post 288698 (slappy: «Hmmm. no.», Methods Discourse)
To answer your question, no. There are times for alcohol, and there are times for aprotic solvents.
You’ve gotta love me.
( Hive Bee )
09-10-02 16:19
No 354900
(Rated as: excellent)
Well, I disagree. Morphine is more euphoric than fentanyl.
What few people know is that fentanyl is actually less addicting. The withdraw is not as tough as with morphine / heroin, probably because the dose is so small (and because it is not as good). The only fentanyl that could compete with heroine is probably 3-methyl fentanyl. The narcotic effects have about the same duration as heroin (4 hours). The long duration is due to the pseudo irreversible binding to the receptor.
Furthermore, a positive thing however is that fentanyl does not induce such a histamine release as morphine.
Slappy’s article (cfr supra Post 285252 (slappy: «‘Re: Easiest way to amphetamine in the kitchen+Fen», Methods Discourse) ) is available here:
Design, Synthesis, and Pharmacological Evaluation of Ultrashort- to Long-Acting Opioid Analgetics
Paul L. Feldman, Michael K. James, Marcus F. Brackeen, Joanne M. Bilotta, Suzanne V. Schuster, Avis P. Lahey,
Michael W. Lutz, M. Ross Johnson, and H. Jeff Leighton
J. Med. Chem. 34(7), 2202-6 (1991) (../rhodium/pdf /ultrashort.u ltrapote nt.fenta nyl.pdf)
Ritter, please, post that PDF!
Antoncho
( Chief Bee )
09-10-02 22:18
No 354977
(Rated as: excellent)
4′-Arylpyrrolomorphinans: Effect of a Pyrrolo-N-benzyl Substituent in Enhancing sigma-Opioid Antagonist Activity
I just wanted to straighten this out. Again, just because a compound is more powerfull (lower ED50) it doesn’t necessarily imply that it is better and / or more addictive.
Furthermore, p-fluoro-fentanyl seems to be more morphine like than fentanyl.
The order of receptor affinity of morphine is mu > delta > kappa, whereas in fentanyl and sufentanil the order is somewhat reversed (mu > kappa > delta). p-fluoro-fentanyl has the same order of binding affinity to the receptors as morphine, with the only difference that it binds
49 x stronger to the mu receptor,
7 x stronger to the delta receptor,
and 5 x stronger to the kappa receptor
than morphine.
For comparison, fentanyl binds
7 x stronger to the mu receptor,
0.9 x stronger to the delta receptor,
and 2.8 x stronger to the kappa receptor
than morphine.
And sufentanil binds
24 x stronger to the mu receptor,
3.7 x stronger to the delta receptor,
and 14 x stronger to the kappa receptor
than morphine.
How to Make Methamphetamine
Pseudoephedrine Acetate
Just a reprint. What do I think? Well, I would like the titled material to be analogous to chloroephedrine, but this is just a salt of the amine using acetic as the acid, a result of the isolation process from pills. Much of it is in traffic in Mexico; apparently the superlabs also purchase material which at one time was in pills. The second article is about a seizure.
Meth Synthesis W/ephedrine, HI, Red Phosphorus
by Cousin Singe
NOTICE: TO ALL CONCERNED Certain text files and messages contained on this site deal with activities and devices which would be in violation of various Federal, State, and local laws if actually carried out or constructed. The webmasters of this site do not advocate the breaking of any law. Our text files and message bases are for informational purposes only. We recommend that you contact your local law enforcement officials before undertaking any project based upon any information obtained from this or any other web site. We do not guarantee that any of the information contained on this system is correct, workable, or factual. We are not responsible for, nor do we assume any liability for, damages resulting from the use of any information on this site.
All you people who want an easy meth systhesis – They don’t exist! You have to know some chemistry. Learn some (yes it takes some discipline) or be doomed to fail.
So, again, this information is posted for information purposes only. I accept no responsibility for anyone actually using this. If you do you will be subject to state and federal laws and will be subject to fines and/or imprisonment. If you are stupid enough to actually manufacture meth you WILL probably go to prison. This is the 90’s.
So to make meth from ephedrine- Using l- or pseudo ephedrine place 1000 gms of ephedrine, 250gms of red phosphorus, and 1000ml of hydriotic acid in a suitable round bottom flask. Fit the flask with a reflux condenser and reflux the mixture for 48hrs at 120 degrees C. Add a 10% solution of sodium hydroxide until the Ph is 14. You should get an oil layer and a water layer. Separate the oil layer in a separatory funnel and put it a flask with 3 volumes of water. Rig the flask for distillation and distill the oil water mixture until the oil is mostly gone (except for highly colored globs of oil.) In the reciever flask there should be two layers, an upper oil layer and a lower water layer. Separate the oil layer and mix it with 10% hydrochloric acid until the Ph is 7.6. evaporate the water and it will crystallize into methamphetamine hcl.
“We have observed that mixtures containing red phosphorus, iodine and either concentrated HCl or glacial acetic acid do convert ephedrine to methamphetamine; however, when the phosphorus is omitted, methamphetamine is not formed. Ephedrine was reacted with red phosphorus and iodine in refluxing water, varying the ratios of red phosphorus and iodine; when red phosphorus and iodine are in excess of ephedrine in a 1:3.8:7.2 molar ratio (ephedrine:red phosphorus:iodine) methamphetamine is formed and the ephedrine is consumed in 8 hours.”
Anyone have any thoughts, experience with the typical E-RP-HA when the usually separate step of creating the hydriotic acid is omitted and the three chemicals are just reacted in refluxing water. It seems like that is what is being described (along with acid substitution).
1. 30ml bottle tincture iodine containing 2% iodine, sodium iodide 2.4%, alcohol 47%, rest H20
2. 5 Sinustop Herbal Decongestant tablets containing 60mg crystaline pseudoephedrine HCl each mixed with some herbal ingrediants. Or 300mg of ephedrine obtained thru some other method.
3. 5 road flares.
4. Bottle of drain cleaner containg conc. H2SO4
5. Bottle white distilled vinegar
6. Red devil Lye containing sodium hydroxide
7. Spray can of brake cleaner containing 1,1,1 trichloroethylene or 1,1,1 trichloroethane
A. Purifying pseudoephedrine:
1. Take the 5 decongestant capsules, empty their contents into a small funnel with a coffee filter. Pour 50ml of cold water through the filter, and collect the liquid in a small jar.
2. Add a 1/4tsp of lye to the collected liquid. You should immediately smell the odor of ephedrine.
3. Put the resultant solution in another small jar, and add 50ml of brake cleaner, then close the lid and shake vigorously. Let stand so that the layers seperate.
4. Using a turkey baster, suck up the bottom brake cleaner layer out of the jar and put it into a small bowl.
5. Add 50ml of vinegar and heat the resultant mixure over low heat in a frying pan with 1/2 inch of water. Thus a water bath. Do not use a gas stove, since the brake cleaner vapors will produce toxic phosgene if there is contact with a flame. Instead use a hot plate or electric stove at low heat only.
6. Heat the bowl in the water bath until no more liquid is left. At the bottom will be a solid layer of a pseudoephedrine acetate.
B. Preparing the red phosphorus:
1. Scrape the red phosphorus off of the caps of the 5 flares and store for later use. You should get about 0.1g per flare.
C. Preparing the iodine/HI solution:
1. Pour the entire bottle of the iodine tincture into a small ceramic bowl. Heat on the above type water bath until no more alcohol is left. Let cool, put in a small polyethylene jar, and add 0.1ml of the H2SO4 drain cleaner. Thats about 1/4inch of liquid in the end of an eye dropper. This converts the sodium iodide to HI. You now have a solution of iodine and HI. 2. Add the red phosphorus, and heat bottle in a water bath until the purple iodine color goes away.
1. Add the pseudoephedrine acetate to the solution of HI/I and phosphorus, and heat on a water bath for 24 hours.
1. Cool the reaction solution and add 1/2tsp of lye. Take the solution and perform steps A3-A6. 2. You will end up with methamphetamine acetate that you can scrape from the bowl.
Congradulations! You have circumvented all of law enforcement and have greatly contributed to the end of the “drug war”. (or contributed to the outlaw of all flares, iodine tincture, vignegar, drain cleaners, and auto store chemicals and coffee filters as will happen in the next year)
Best regards, Cousin Singe
If methamphetamine looks waxy or oily, it is probably contaminated with the HI salt of meth, an oily by-product of the red-phosphorous/HI reduction of ephedrine–the most prevalent method of clandestine manufacture.
The HI salt is soluble in acetone, while the HCL salt is only very slightly soluble. The HI salt could be washed out, basified, and then precipitated with HCl gas to give methamphetmine HCL.
When completely dry, methamphetamine HCL is soluble in chloroform, while ephedrine HCL is not. This would provide a convenient method of separation.
[Reference: Skinner, Harry F., “Methamphetamine Synthesis Via Hydriotic Acid/Red Phosphorous Reduction Of Ephedrine,” Forensic Science International, Vol 48, 1990, pp. 123-134]
M1A2 Abrams United States
The seizure reflected the vast scope of an illegal drug trade linking Asia, Mexico and the United States, officials said. Two of the seven people arrested Thursday at a faux Mediterranean villa in the Lomas de Chapultepec neighborhood were Chinese nationals.
The group was part of a larger drug-trafficking organization that imports “precursor chemicals” from companies in India and China for processing into methamphetamine in Mexican “super labs,” authorities said. The methamphetamine is eventually sold in the United States.
The raid resulted from an investigation that began in December, when authorities seized 19 tons of pseudoephedrine, a cold medicine that is a key ingredient in the production of methamphetamine, at a Mexican port on the Pacific Coast.
A legally registered Mexican company, listed by a trade association as the country’s third-largest importer of pseudoephedrine, was implicated, officials said.
Mexican drug-trafficking organizations have become increasingly important in the U.S. methamphetamine trade, because the U.S. has imposed tougher controls on the sale of the chemicals used to produce the highly addictive drug.
President Felipe Calderon hailed the seizure as a major development in his government’s war on drug traffickers, who have ravaged several Mexican cities and towns.
“We are working in a decisive manner to save our country and to keep Mexico safe and clean,” Calderon told an audience in Tijuana. “I don’t even want to imagine how many young people this gang poisoned with its drugs. But I can assure you, they will do it no longer.”
“Kudos for the Mexicans,” said Donald C. Semesky, financial operations chief for the U.S. Drug Enforcement Administration. “They’re very serious in this effort, and we commend them.”
Officials with the attorney general’s organized crime unit used a moving truck, guarded by a 25 patrol-car caravan, to take the money to its headquarters.
Authorities said the traffickers were led by a naturalized Mexican citizen of Chinese descent who appeared to have left the country.
Several machines for manufacturing pills were found at the site, but the group did not produce drugs there. The mansion appeared to serve as a financial operations center and cash storage facility.
The neighborhood is home to some of the capital’s wealthiest residents and many members of the diplomatic corps. The back of the property is contiguous with a racquetball court at the Ukrainian ambassador’s residence. The Israeli Embassy is a few blocks away.
Most neighbors and the many maids and security guards who work in the area declined to comment on the raid. The few who did said they had no knowledge of illicit activity.
“The problem is that all of these houses are veritable fortresses,” said one of the neighborhood’s security guards, who asked not to be named. “You never know what goes on inside. The doors open automatically. The owners all have chauffeurs. People go in and out, and you never see anything.”
A driver-bodyguard arrested at the house had told neighbors he was a retired lieutenant colonel in the Mexican army. Neighbors said he walked a German shepherd along the tree-lined streets.
Authorities said the chain of events that brought police to the mansion began in December, when they discovered a shipping container filled with barrels of pseudoephedrine on a storage lot at customs offices in Lazaro Cardenas, a port city about 175 miles northwest of Acapulco.
The chemicals had been manufactured in China and shipped to Mexico on a British-flagged vessel that was bound for Long Beach. The seizure led authorities to a chemical company, Unimed Pharm Chem, based in the city of Toluca, about 40 miles west of Mexico City. The company reported legally importing 32 tons of pseudoephedrine in 2004.
“The resulting investigation showed that this company illegally imported … pseudoephedrine acetate from India,” the attorney general’s office said in a statement. “These chemicals are used to illegally produce methamphetamines.”
Mexican Atty Gen. Eduardo Medina Mora said in a radio interview that one of the Chinese exporters involved in shipping the chemicals to Mexico is an illicit “shadow” company not registered with Chinese authorities.
Last year, Mexican authorities raided what they termed the largest methamphetamine lab in the Western Hemisphere at an industrial park in Guadalajara. The factory had 11 custom-designed pressure cookers capable of producing 400 pounds of the drug each day, about 20 times the production of a typical California lab.
Saturday, August 16, 2008 Guadalajara
U.S. officials estimate that 80% of the methamphetamine sold on U.S. streets is produced by Mexican criminal organizations.
For these drug cartels, whose business mushroomed when they became the middlemen in the shipment of Colombian cocaine to the United States, methamphetamine is a lucrative side business worth billions of dollars, analysts say.
$100 bills preferred
“They don’t want to build a storage location for 20s,” the DEA’s Semesky said of the drug traffickers. “You’re talking about decreasing that bulk at least five times.”
Mexican officials said they worked past midnight Thursday to count the seized bills, which were hidden inside locked metal shelves, suitcases and closets. It was five times the amount that was seized in all of 2006 by Mexican authorities in anti-narcotic and money-laundering operations.
To provide a sense of the scale of the money involved, Mexican media compared the amount seized to various items in the 2007 federal budget.
“It’s a lot of money, and we didn’t know a thing,” said one security guard assigned to a nearby property. “We work outside and can’t even imagine what goes on inside these houses.”
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138 Responses to “Pseudoephedrine Acetate”
This was a Great wordpress post, I will be sure to save this in my Mixx account. Have a great day.
Hello guys and girls, just wanted to put my first post in the into area and say hi and glad to be here.
hi everybody i am an iranian boy and i am so excited because of this site i love chimestery and making met but i cant because the materials and their prices i am searching on a flower as efderia for pure pseudoephderin if you can help me sorry for typing bye.
Amir, you don’t need meth. You need Jesus! He’s the only one who can heal the pain in your heart. He knows you and your situation and He can help! Satan hates you and will do everything in his power to destroy you, but he trembles when the name of Jesus is spoken. God knows you and he cares. He loves you Amir!
jesus isnt real
See what I mean?
hi! Ive been searching information about how to cook meth. I dont really know much about chemestry but I want to be sure about what to do, I dont want to cause an explotion or something on my first time. If you know a much simpler or faster way to cook it please reply the link.
thanx!!
hola,tengo pseudoefedrina y me gustaria cocinarla con el metodo de fosforo,sabes darme algun consejo,contestame porfavor,gracias y un saludo
If You dont have any chemistry knowledge then this isnt for you. making meth is difficult and dangerous. No matter how carefull you are you can still have an explosion when you gas it off or even filter it, Best advice hang out with a professional cook with up to date recipies and good quality lab equipment,
@number Three there are three layers of cake the middle layer looks like icing.
@5 the distilled vineger is layered on top is this correct?
why dont you just give them some coffee?
Coffee isn’t real.
At the time I wrote this post I speculated that pseudoephedrine acetate was found in Mexico because it must have originated from the diversion of pills, and the use of acetic acid was explained by the difficulty of obtaining other acids in Mexico.
It is my belief that some knowledge can be gained from any seizure if you have figured already that there is ephedrine and pseudoephedrine, and there is natural and synthetic. While both of these configurational isomers may be made synthetically, an ephdra plant can only make ephedrine. All of the pseudo is synthetic. That means, of course, that the mechanism by which dope appears is certainly more corrupt, since it takes a giant, government-sanctioned plant to manufacture chemicals, and that there is no possibility that simple agrarian means are used to circumvent the law.
In addition, I wonder how I could have missed the application of “pseudoephedrine acetate” being the R-OH —-> R-H intermediate such that the one time R-OH —-> R-Cl —-> R-H method (Emde, 1929) now has a method summarized R-OH —-> R-OAc —-> R-H, using an electrochemical cell, meaning that once more, the need for precursors of any kind is made moot. We can use electricity instead of buying new chemicals. This intermediate is a “pseudoephedrine acetate”, where the acetate group is part of the molecule and not just the counterion in an acid-base salt.
Your second source claiming that pseudoephedrine hcl is now 10,000/kilo, is not only grossly exaggerated, but retarded. Not even close.
[…] Pseudoephedrine Acetate « How to Make MethamphetamineThe Show-Me Institute’s Official Blog. … As Stokes pointed out, putting pseudoephedrine behind a prescription likely wouldn’t stop meth production. And on top of that, it would make the medicine prohibitively expensive for many. […]
Hello. Do you have anything to say on the subject of methamphetamine manufacture?
meth is bad mmmmmkay
Is it worse than a Cleveland Steamer?
The serbian guy forgot about the iodine, my pet frog says. He needs to learn to google, the frog said again.
The frog also said who cares about the acetate vs HCL. Both have the same affect. Frog also thought the acetate form is maybe easier to snort to avoid meth smells for smokers.
Frog thinks putting this receipe out there, with details to produce such a small amount, is going to encourage a lot more home cookers again, since getting such small amounts of precursors will make it impossible to track.
Frog thinks the US DEA may go stupid and ban psuedoephedrine, as it will only lead to chenists finding a new precursor. Frog has read papers on how the replacement for psuedo can and does make meth too, and worst that replacement will actually make meth cooks learn how to make ecstasy too….something the current meth process won’t show most meth cooks who are not trained chemists.
Frog ended by thinking how stupid the US was and is to trust the Mexican govt to find the fake money….some of the money will be stolen by the corrupt wetbacks.
Frog thinks the money should be used by the mexican govt, but that fighting meth gangs is like fighting cocaine gangs. It will never end. Stop trying to stop wetback meth makers, and just keep them out of the USA. Let US home cooks blow themselves up or die from poison gas since most of these “receipes” don’t say how to avoid the deadly gas in a given phase for one process, how to watch pH, or how to avoid explosions with pressure gauges in another process.
What does a frog now.
I love pork, I love jews, and I love to feed meth to other ragheads so they die. I give them 10g a day so they die quick and fast.
Piger imagines Jessica is dumb. This receipe makes a tiny bit of meth so small it can’t get an ant high. It is almost idiot proof except for one stage where the poster warns of gas but doesn’t warn you can still die because he doesn’t mention the simple safety.
piger thinks if jessica must try for the easiest way and the safest way, she better follow the meth HCL normal RPI method by Fester and she better remember why two bottles are used with a hose running from the cooking jar to the other jar with water. It is to save her life if phosphene gas gets too high and she passes out.
Piger is confused. RPI does not blow up. That is the nazi method. RPI only blows up people dumb enough to mishandle ether or light up other solvents to clean pills or when bubbling HCL to make crystals.
Piger is a character in a play written by a frog. nothing piger writes is real about feeding ragheads meth….but he does love pork.
Some people like frogs.
Like Che Guevara.
Jesus drinks coffee.
I’m wondering – has anyone ever carried out a steam extraction of (pseudo)ephedrine from pills to get their precursor? It’s in both of Fester’s most recent books, but I’ve never heard of anyone actually carrying it out successfully. I’d like to just forget about it because it seems overly complicated compared to other extraction methods I’ve heard described, but the only other method I’m aware of that cleans pseudo enough for a emulsion-free Red P/HI reduction involve the use of trichloroethylene from brake cleaners, but none of the brake cleaners on the shelves of my local shops have trichloroethylene in them anymore (including CRC). Here’s a little run-down of the steam extraction process (not exactly verbatim, but relatively close thereto):
“Tubing is run from a sealed pressure cooker to a glass tube with a jetted tip, which jetted-tip glass tube is directed into the side-arm of a 2-neck flask containing an aqueous (pseudo)ephedrine solution (containing a bit of HCl to prevent too much water from evaporating away to help maintain the original volume of solution). The steam travels through the top of the flask and through a condenser, and the contents of the receiving flask (post-completion of the steaming process) are simmered down to about 20% of its original volume. The (pseudo)ephedrine alkaloids are then based and extracted with a NPS, and the extract is gassed for fairly pure crystals of Pseudoephedrine HCl.”
Giving you the finger,
Steve
I hadn’t read the portion of Fester’s book that contains this extraction technique (Secrets of Meth 8th Edition, Pages 129-131) for some time before posting that rough outline of the process. I read over it last night to determine what I had botched in my post. The boil-down occurs after throwing a shot of HCl into the steam distillate. I’m not too concerned with the actual steaming portion of the process; I’ve performed this portion with no hassle (not as the apparatus is shown in the book, but with a traditional essential oil steam extraction setup). However, as I was reading through the book last night, I noted that Fester gives mention to the *idea* of boiling down the acidified steam distillate to dryness, and then scraping up the crude pseudo from the baking dish (or other drying vessel) and recrystallizing it in some hot acetone or washing it with some cold acetone before proceeding with further purification. Now, as I read that there may be a way to come out with clean pseudo without having to base and gas (I’m not a fan of gassing – especially without the proper tools to concoct a suckback trap readily at hand), I thought back to another method of pill extraction that I had been instructed to employ while I was being educated on variations of the Birch reduction. This method consisted of grinding up the pills to a powder, placing the pill mass into a jar containing methanol, and then placing the jar into the freezer for three hours (I determined with experimentation that the three hour period that I was instructed to adhere to was to bring the temperature of the methanol to below 0 deg. F.). After the three hour period had elapsed, “the waxes and binders should be frozen”, and could be filtered out before the temperature came back up too much. Once the solid components of the jar had been filtered out, the filtrate could be simmered to dryness, leaving crude pseudoephedrine in the baking dish. I repeated the whole process two more times with the crude pseudoephedrine to try to get out as much of the garbage as I could. I’m wondering, now, if I could recrystallize this semi-clean but still fairly crude pseudoephedrine in hot acetone. I envy your extensive knowledge of the subject, Steve, and greatly appreciate your constructive criticisms. What are you thoughts on recrystallizing pseudoephedrine that was pretreated as described above? I’m fairly confident that a lot of the binders and gaks are removed with this technique when using a Pyrex fritted disc filter funnel as opposed to a standard Buchner funnel with filter paper as most home chemists are accustomed to using, buf I value your opinions because you’re a seasoned chemist and you take the extra step of analyzing the different components of these techniques to weed out the best route to take or what routes to avoid altogether. Kudos 😉
when you said this…I hadn’t read the portion of Fester’s book that contains this extraction technique (Secrets of Meth 8th Edition, Pages 129-131) for some time before posting that rough outline of the process. I read over it last night to determine what I had botched in my post. The boil-down occurs after throwing a shot of HCl into the steam distillate.
Then it gets to the boil-down, coming back to a meth isolation process, because that’s what I tried myself. And, my meth oil was in a top layer, but I saved all the water layer, too, figuring it might have a lot of meth, but the amount was low, less than a gram per liter. I knew that because it was almost unbuffered; it took only a few drops conc. HCl to neutralize. You must determine how pseudo partitions between a layer of it and a layer of water; it’s probably better than meth since it has a hydroxyl group, water has a hydroxyl group, and, like dissolves like. But, it is going to freeze, too.
The idea of a methanol extraction by freezing out insoluble matter is to invite blindness. Methanol is a specific toxin for the optic nerve, it is cumulative, it is absorbed through the skin.
People who use methanol might wear masks, masks prevent breathing stuff in, the right kind with charcoal. But, I transfer it from a sealed bottle, I only have it open a minute, into an alcohol lamp, and, I am putting that into a paint can first chance I get. You don’t want to make a habit of standing over a vaporous funnel full of methanol.
Read the old school stuff when they used it; they even went ahead and extracted with benzene, and they didn’t trifle with methanol. Ethanol’s fine, acetone is very forgiving on poisoning and will burn us. You don’t need the top solvent for the job, just more of the second choice. If conditions have ramped up the risk for the right things, it’s going to be a rough ride.
Zero-odor, zero-flame, zero-solvent processes are called ‘click chemistry’. The HI with steam is the closest to that I know, although I boiled it with phosphorous still in it once and it made me sick and high. I’d filter out that P twice before I did anything else with it.
I don’t know about binders in pills, just mainly that the cops will kill you for smurfing. When I did it, “D&E Phramaceuticals” on the back of High Times would charge about double for the contained material and only kiss it with chalk, during 1990. It was made to be extracted, is my point. If it’s made to foil diversion, you got to give them the benefit of the doubt, see? We’d usually go around one last time with the people who supplied it last, make them supply it again, but, that’s been done. Now they’ll get it either way they go, so, give it to ’em. “U can’t make suzy and not make it for me, bitch”. Whatever, war’s a crying shame.
When you find out how it’s done, don’t forget to kick down, turkey. With the method.
Let’s go home. Don’t just keep driving that train, high on cocaine.
That last post is interesting.
Click chemistry….nice term. Boiling or water baths with no “safety” (you suggest boiling in a ceramic bowl (I went and assumed you meant something strong made of a brand I won’t name made with layers of bors…glass (i.e. sheets of pyrex grade glass)….nice! Are you trying to kill your readers? I’m sure the “assumption” is that phospene gas isn’t produced at this reduced level (via steam) but you know how frying pans vary, ceramic bowls do, hot plates go bad, and the gas has no odor….speaking of killing the audience.
Contrary to all the self alleged “chemists” out there, why not just had them get a read good quality mason jar and run into another such jar, drill 2 holes between the jar to steam boil (cook) and use the tube to capture that gas you assume won’t occur?
Let the Serbian, Iranian, and whoever die their natural meth death! hehehehehehhee
where to begin…
“click chemistry” is not an interesting term. Similar to “combinatorial chemistry” or “fractals”, it’s a whole giant way of looking at chemistry (cf. “nanotechnology”, “green tech”) which did not exist twenty years ago, and, it is not for you to muse on, it is for you to Google and to get started putting into practice. Barry Sharpless, a Noble Laureate, invented it, and he has been brought here to San Diego. We have him. The prototypical genius is Corey of Harvard. He invented LHASA, logic and heuristics applied to synthetic analysis, a computer program, in the ‘Seventies. The enterprise of chemistry has a thousand genius-level researchers at any one time. It’s mankind’s last best hope.
Your style is the bemused observer of a typical voyeristic society, but cooks are outlaws and rebels. The computer is what escaped the laboratory and brought know-nothings like you into it. Chemists make weapons of mass destruction, but let’s get real. This wasn’t invented to be a weapon. It’s a sticking point we use to fight for our freedom with, in the knowledge that otherwise we are marginalized from society and made to feel like surplus population. Your so-called industry of rehab is just another self-perpetuating myth, brought largely along by a cowardly social ethic which refuses to punish behavior as a crime, and instead asserts that a grown man is in the grip of a drug he can’t control, or other ridiculous lies. If somebody takes drugs, it is because they must want to more than they care what happens because of doing it.
I’m staring at your text, at a loss for words. “Hot plates go bad”. Right. How do they do that?
Didn’t I tell Xv that methanol was poison? And, you have no way of knowing, but, this is frequently the platonic dialog that goes on. he just wants me to repeat things I’ve said before, because it’s important. So, “Abe Lincoln doesn’t care”? You mean the government doesn’t care? So what else is new? The government officials must be held accountable for the 35,000 deaths by gun violence in Mexico to support an appetite for drugs in The United States. No-one can be complacent in the face of those numbers, not the money. We didn’t kill them in the years 1990-2000, so, what has changed? It looks like we exported the death (if not the high) in the worst possible way, akin to how the British killed thousands of Chinese in the Opium Wars. The British were not “con” on opium, they were “pro”. The Chinese wanted it gone since it was decimating Chinese society in their homeland, a good excuse to fight if I ever heard one.
Wikipedia
The First Opium War was the beginning of a long period of weakening of the state and civil revolt in China, and long-term depopulation. In 1842, China’s population was over 400 million, of whom at least 2 million were opium users. By 1881 the country’s population was less than 370 million, of which as many as a third made regular use of opium.[27]
I don’t want these people to be dying. Many die due to the status quo. Telling how to make meth is not evil intelligence which will cause one to go bonkers. It’s inclusive of the physical basis of reality and is adequate matter for discussing truth in order to extend the great work and not make wild speculations about my “assumptions” which you have no way of knowing.
Phosphene (you misspelled it. There are over a million chemicals in common use. What do you think happens when people are sloppy about spelling chemical names?), most certainly is produced in a steam distillation, as are vapors of the material of interest. That’s why we want the phosphorus out. The vapors during reflux are removed by a gas scrubber (this site). DEA doesn’t publish better syntheses, because they are playing a game for keeps which kills their prey by any means available, through every trick in the book. It’s pretty obvious drugs kill people not because of their preventable effects, but because of the intentional effect of the enforcers of the law, like declaring war against the poor.
“Trpiodine” is obviously misspelled. We don’t have any syllables where p follows tr, but, I am aware of DEA “fingerprinting” batch production methods, as well as other harebrained schemes designed to stop everything from fertilizer bombs to nuclear weapons, as well as assertions that aziridines result from the HI method. We aren’t product-liable. We are disarmed combatants subject to slaughter by an oppressive regime. All the millions of deaths and lives spent without hope for advancement is a crime laid at the doorstep of the powers that be. LE got all the anti-precursor laws they asked for.
Painters do not wear any more than a surgical mask against particles, since they enjoy the toluene high. The proper thing has a rubber seal against the face, no beards, and replaceable cartridges of a type specific to the contaminant, like, “organics”. It’s a seventy-five dollar item, well worth the money. I cooked while I was piss testing on probation using that, but, I tried to do product and there is no five-day period to get it out of the system. I got a dirty even staying clean five. I don’t recommend seven, either. I think I recommend fighting the case. They have a sixth sense whether you are using, and will just raid you the day after testing you the day before.
Tonya Harding is on TV now. She was convicted of having Nancy Kerrigan beaten with a stick. Kerrigan went on to get the silver medal on a sympathy vote. She’s as ugly as Katharine Hepburn, who was the typical Parkinson’s vic for decades. This disease has an environmental form only discovered by illegal drug manufacturing, so science owes us, funny how they do not acknowledge the debt. But, I wanted to add that with toluene and nitrous oxide, I can sit here and do six different drugs in relative safety. You can get a head-ringer in a grocery store within ten minutes from right now just off the Reddi-whip can held straight-up, and put back behind some olives after you partake. Just hold onto the basket so you don’t fall. And, fill it up with luncheon meats and brezad, turn a corner into the area you’d go to the rest room in, scarf a sandwich quickly, and abandon the cart and leave the store. They won’t catch on unless you go back too many times. But, Tonya said, “Nothing goes up my nose but a finger to put a booger out”, she had to clarify since she is on a show with Busey and Bonaduce.
need your advise and opinion, with regards to the red phos hydro acid method.
using 50liter glass reactors. basic run through the proceedure as you would see it would be great if you have time.
mass production technique. thanks man
I’ll leave it to anyone, chemists or not, with some patience to think out how to avoid the smell of opening the cook flask (clue: bathroom, lots of hot steam, HVAC or at least full body cover flight suit with painters fume mask, full suction fan on on the top floor or out in a country house with no neighbors for at least 2 acres, OR learn to make a simple FUME HOOD.
Pay with bad crap, your life, or pay for lab grade mexican stuff….whatever you do, most of those here will end up in my industry eventually or dead (clue: rehab and user detection).
abe – I’m not egotistical enough like so called “home chemists” or crank cooks to call myself a “cook” or chemist. I’m just the guy that reverse engineers their little games, finds out how they poison themselves, and eventually end up talking to a roomful of idiots who wonder in awe when I mention most of them die not from the meth but the POISONS they get in their kitchen crank (and no I don’t mean the LEGAL kitchen grade, dirt crank. If meth kills, most anti-meth orgs, moms, and lesser informed LE misses the reality most are not from OD or meth itself, but the years of gearheads tweaking deadly levels of trplodine, sucking in deadly levels of iodine and phosphorous, and the HIGHER cardiac risks of undercooked (that means pfed/efed) meth vs. meth. Most of your cheap self bakers are going to die from these and not abuse of real meth….that requires something called “lab grade” meth.
How do crystalize shake
You are as high as a kite bill. The computer escaped what? Chemists are not computer scientists. And so called home chemist cooks are just cranks, crank cooks…live with it.
In what land do you live. Therapy is something that happens for the convicted and the ones who get help before being forced to go or serve harder sentences…it’s a term called mercy.
Addicts don’t WANT their drug at the start…half the time people like you misinform them or they are just stupid. Others know full well, either way the WANT isn’t what leads most to long term addiction….it starts as a game and ends as a nightmare….it doesn’t take a genius to know you play with the ice yourself….but your kind always thinks you can get away with it online…you probably will and be too stupid to know how many years you shaved off, or maybe you are one of the few not dumb enough to think you didn’t cut off a few years or decades….depending on if you’re an injector, multi-G smoker, or ice/coke/crank-crack addict.
Learn to check the clan chem stuff you repost…..I just caught a major error in your little meth acetate piece once again….where is the dope genius? In what ingredient?
Painters often don’t wear masks to get high on the toulene, or now xylene? So what? Many DON’T…..just a ones that want to blow their brain do…..know or bother reading how many of their friends who did talk about how the ones who did are half gone mentally with 1/3 of their life left? Brains….use it.
The reference is to things which are impossible until some geeks create a machine to do them, in accordance with the setting for it, a lab. What looks good on paper sometimes makes life worse for people who must contend with it. Once it’s no longer confined, how do you control it?
I’m not going to get into mistakes I reposted. You are not saying I said something with a big mistake in it, just to be clear. And, you went back 400 posts to do it. Can we move on? I’m at Post #729. I know there exists a detailed and warped recipe if I ever need to reference it.
The dope is in the suzy, not the acetate.
No more questions.
I do not like the tone of this thread, it’s tendentious:
Expressing or intending to promote a particular cause or point of view, esp. a controversial one: “a tendentious reading of history”.
marked by a tendency in favor of a particular point of view : biased. — ten·den· tious·ly adverb. — ten·den·tious·ness noun. See tendentious defined for …
The author’s tendentious history of the chemical company …
Ooh, jeez. Fifty liters, huh? I had noticed that heating pure water to its boiling point proceeded smoothly; I could heat it at a degree per minute, so I didn’t overheat it. But, something like a reaction doesn’t behave that way. While you are getting it up to reflux temperature, the reaction kicks in and dumps more heat into it, causing a runaway heating effect, and it boils all at once, shooting all over the place. Start smaller, run it until you get familiar, scale it up. It’s on here as “recipe #1”, or, “Recipe from 2006”.
What part about the scale-up do you not understand, Adam?
ok, thanks man, you basically reassured me, i agree with your points. i was wondering if the reaction time differed, when the scale is a bit higher?
thanks steve
Objection, nonresponsive. Consider I get overruled. Of course it takes longer to heat a big batch up. Don’t speed that up. Temperature is an intensive property. It’s the same everywhere in the batch. Volume is an extensive property, imposed from the outside. One of ’em is in theory; we have state functions like Gibbs free energy. Heat only has meaning when it moves from place to place, so, it is not a quantifiable measure of a system. Time, well, a rate is “per second”, and, seconds are time. But, the word rate applied to things other than time, a rate of change of something else, I think is problematic in theory. There aren’t any other changes except those happening in time, so, we can’t output it so well. The old rule before the Arrhenius rate equation came in said for every increase of ten degrees C, the reaction rate doubles. Don’t try to make up time on the road, you’ll have an accident. So, why try to mess with something which is already standardized to fit the work day? Just leave it boiling, take a sample, if it works up to crystal, cut off the heat, then you tell me how long it takes. But of course, nobody ever does, so, how do you people expect me to know?
I’ve been pondering on this for a few days, and I’m hoping maybe you have an answer or want to theorize.
For a small scale Red Phosphorus/Hydroiodic Acid reduction (we’ll use 10 grams for this example), how long does the reaction last before heat is *required* to continue with the reduction? I know that most employ a gentle boil, but let’s assume that the chemist has all the time in the world at their disposal. Would the reduction eventually work itself to completion as long as the Red Phosphorus remained in contact with the Hydroiodic Acid? Or is heat absolutely necessary to produce a fully reduced product? Does the Red Phosphorus eventually lose its catalytic value? I guess the best way I can ask this in so many words is: If HI, RP and Pseudo are left in contact with one another with no external source of heat, would the Pseudo eventually become fully reduced?
I do not have time to theorize this morning. I doubt meth changes back into pseudo, but it may change into aziridines, or pseudo may. You have any number of competing reactions. The yield of what we all want, so that we can get fully reduced to not even human, will exhibit a maximum at an optimum time and temperature value. You want to stop it there. But, this is not under equilibrium control, so, it must be kinetic control. But, without reflux to agitate it, who is going to stir it? A heater only costs two hundred bucks, a stirrer costs five hundred.
intro to forensic chem of meth, see section on HI/P
I can’t help when idiots expose themselves.
To ask how hot plates go bad and call oneself a scientist. You write about “click chemistry”, so the hot plate in question would not be a lab grade hot plate but obviously the one made for home cooking (of food)….they run on electricity….they go bad with age…..real scientists, people called engineers designed them you know.
Your other poster proved my point on the other error. At least you got it right that the dope is not in the water…BUT notice the suzy is at the top and not the bottom…go figure…that is ALWAYS how ether floats with water….chemist? if you can’t read the short acetate post and catch that, you are a reason we need english as an official language and you need to get more “hands on” again. Even someone who’s never cooked before knows ether floats…it’s called READING.
At least you weaseled out of the high production guy’s questions. God help him if you blow him up with your click chemistry and open containers.
Okay, brother. Take it easy. I will get more hands-on again.
Go to India and Pakistan….no 10,000/kilo pfed there. That number is speculated by people who add in estimated costs of layers of overseas companies….a smart drug lord will run firms between countries where no more than 2 nations will cooperate easily…..but even then, the cost is falsified by “ass”umptions by a meathead of academia vs the meatheads of the farm belt that cook nazi style.
If pfed cost that much, coke would cost less than meth….it is the opposite….and coke is king for cash flow still because meth is too easy to make….go figure…..multi-source your “truths”.
Suzy comes in to, say, Argentina. At least it did before the Argentine kingpin of it got caught. Right now, I’d say it comes in to Venezuela, the revolutionary Chavez regime, or, to the Evo Morales government in Bolivia. Evo’s second term runs out in 2014. Overland smuggling routes exist throughout S.A. The Panamanians have a porous entry point at the airport, Tocumen. Loads are broken up and driven north to Mexico. Evo ran on a platform of the people. He was a cocalero, and they have a union where they say that the traditional use of the leaf should not be interfered with by America, that it would be like him telling Coca-Cola to change their formula. Things like that make it less than a cut-and-dried proposition on how to stop it. The governments lack the will to agree that a substance is bad. The war in Afghanistan has made it easier to traffic narcotics. The ethical drug companies release chemists during cutbacks. But, I still don’t know everything about it. The recent capture of a cartel leader in Mexico means it should be possible to study what he knows, assuming he can be made to tell, but, that data doesn’t make it out to me. The nuclear problem is #1. Your attitude towards me sucks. I believe that education is the key to freedom. Slavery to a drug addiction is not freedom. Outlawing things the people want to do only gives them contempt for the law. We’ve r4ecognized for decades that the narcs inflate the value of seizures through this false method of calculation, as if to clkaim that the scope of the problem is linear with respect to how many doses are contained. If a joint costs a dollar, and an ounce rolls fifty joints, it is not correct to say an ounce is “worth” fifty dollars, but they have done that. The size of the addiction in the entire nation can be pinned to the consumption in the entire nation. There’s no better way because of the social stigma causing the medical issues to be underreported. Nor should they be overreported. Look, if I didn’t make an unqualified claim that it cost 10,000, then I have nothing to apologize for, even if it’s wrong. The blog says, “How to Make it”, not, “How to Jew the price down.”
building a fume cupboard and useing it for this procedure would be a good idea
ok i got a few questions i would really like some one to confirm and give me some help,
q1 – how do i tell the mixture has reacted and i can stop cooking? what signs shud i look for.
q2 – after solvent extraction with toulene, i will be left with the oil rite?or oil and water? or what? then i add hydrochloric acid to it, how much acid and how strong should the acid be? and will it just crystalise quite quickly?
On HI/RP, just take a 5 mL sample and work it up before you destroy the reagent in order to recover the product. The sign is a characteristic smell, and, if it won’t crystallize, it’s still got ephedrine in it. q2 Okay, but, I use steam distillation since that takes care of the crystallization problems and it’s cleaner. Toluene or diethyl ether may be added to the oil layer to build up its volume; you’ll see why when the amount you lose is a constant, but the concentration varies. Acid is reagent grade HCl, 37%. But, it is tricky to get a ratio, say, one drop acid neutralizes a mL, so, split the oil into two in case you go over with acid. If you do, there is nothing I can say. Every way I have tried to fix it then just won’t crystallize. Take some product and base over a solution of it, to see what you are working with. It’s called snot. It could be from another method with an emulsion (difficult to separate layers), so, observe the layers and report back how you avoided an irreversible situation, Adam. Starting material ephedrine is a solid pure, meth’s a liquid.
im using pseudo eph hlc, i am very gratefull for your help man, i hope you will guide me thru the next few weeks wen i try do a few tests, im trying 1kg pseudo, 1 litre ha and 250 gram rp, heated at 120.c for 48 hours in a 50 liter glass reaction vaccum flast. what pionters have you got for me? advice or help would be gratefully taken in, thanks again friend.
How you do it is boil it under reflux; it comes up with its own constant temperature; should be 131 C. Noting these formulas for the volume and surface area of a sphere (your tank), V = 4/3 (pi) r^3, S = 4 (pi) r^2. substituting ten and a hundred for the radius shows that as the flask gets bigger, each cubic cm of material communicates with the outside less, increasing the chance for a runaway reaction. ie V = 4/3(pi) x 10 x 10 x 10 =
4,000, S = 4 x pi x 10 x 10 = 1200, but, that’s 4:1. V = 4/3 x pi x 100 x 100 x 100 = 4,000,000, S = 4 x pi x 100 x 100 = 120,000, or,
40:1. It’s all about heat; when the heated reaction mixture approaches the boiling point, the reaction kicks in and dumps in more heat, so, do that s-l-o-w-l-y. If it bumps, it puts material on the ceiling. You’re welcome.
hey guys, does any one have link to a video of the post reaction workup, would find this helpfull.
hey SB, can you help please, i have more questions for you i hope you can answer cos im gonna try cooking a batch very soon.
1. im using a vacuum temp controlled reactor, is it possible to cook in 24hrs?
2. what colour should the reaction mix be after cooking finished?
3. should i wash the red phos before i use it, as it stains the water dirty purple colour.
4. what colour is mixture after basing with sod hydrox.
5. when i add toloune to the mix it sits ontop rite? does the meth actualy move from the honey water mixture to the toloune? and is the toloune then the liquid i use to add the hdro chlor acid to in order to crstalise?
6. how do i crystalise? how much hcl acid do i add? and do i dilute it with water?
your help is greatly needed and appreciated,
await your reply, thanks man.
You may not be able to leech much more real-time help from this chemist, Slick. Herein lies the tale: Your buddy Strike invented this, “SWIM” thing. It seemed liek a good idea, but, they were fourteen, and, they don’t know a good ideal from a bad idea, cause from effect. So Strike, in the public domain operated illegally right under their noses. Assange operated legally but again, in some speed fraek control central. We keep this low-key lest a wave of poisonings commence over the safety of our… illegal drugs. We wouldn’t want there to be a hack into the safety of your air and water. Besides using a little time to research your questions, I ask you to not bug me with this. Beautiful.
Freebase some coke into crack with a 50 mL screw-top erlenmeyer flask, noting how to shock product out with cold, and, noting the movement of chemicals into phases like solid and liquid. Dude, not only will this meth move into the toluene in any punk-pink phenolphthalein-indicated mix,it will devlop so much pressure doing so it’ll blow the top off the sep funnel if not relieved. I DONT KNOW what purple means, perhaps the stuff came out of an iodiny batch from before. Good, brick-colored P floats on top like a cork. When it settles it’s a beer yellow. When it bases over it is kind of white, the meth is like cooking oil floating on top and it reeks. If it’s solid when cool, that’s got to be ephedrine.
SB, can you explain how to distill the mix? and when? thanks again.
Hypothetically if my friend were to have 10g of pure ephidrine, whats the easiest way to turn it into something smokeable. I cant get any chromic acids so cant make CAT, I dont really want to make anything with RP and Iodine, I was interested in the “Nazi” method – any ideas.
i have purchased red phos, industrial grade, pretty wet and dirty, shud it be wased and dried before its used in the reaction?
I ran a reaction with 400 g. ephedrine HCl, 457 mL HI, 57% inhibited with sodium hypophosphite from the factory, and 50 g. P. The answer to your question is no, but, here’s a what I did: I added water to a 1-lb. can of P, thinking this would stop it from drying out and catching fire. The water added to the P formed phosphoric acid. That ate through the can around the bottom, and, some phosphorus was able to spill out where it contacted the wooden shelf and burned. By the time I saw it, the fire had gone out. I changed the procedure. Now, when I add water to P, I put the whole thing in glass, a mason jar. The mason jar lid sits above the compound and doesn’t corrode much. I am changing this story, though. It’s oxidizers like chlorate that can’t touch wood. They can’t even get dust in ’em or they explode, so, you can’t leave a pile of it out. I don’t know what else you got going on, Adam. You’re pretty ambitious. I’m keeping an eye on your region. What continent are you on? That stuff always looks like that. It isn’t low-grade just becuase it’s wet and looks like brick dust. As for the smell, it doesn’t smell much compared with the meth, but it’s dangerous. Filter it all out before any further steppage like pH raising or steam distill. If the batch condenser water goes dry, it’ll kill everyone who sleeps through it. It’s phosphine http://en.wikipedia.org/wiki/Phosphine, not phosgene. Phosgene, it said, smells like cut grass, while phosphine smells like garlic. It’s not that simple. Just keep cognizant of the maximum amount of chemicals that could have a given amount of wattage under it. Most accomplices will seal you in, thinking the smell will give away the location. Turning over a kilogram bottle of solvent is also a way to wreck the atm. Look up my post on the gas scrubber for another clean air tip.
thanks for quick response, the red phos i have is like small stones, bigger than sand, definatley not like powder, dark purple color. im in Asia, i have secure email if your interested in deeper chat, i will be needing help for sure.
what i cant understand is, why is my reaction mix dark purple after 45hrs cooking, i have read it should be clear or yellow.
Freshly made hydriodic acid will begin to turn dark purple if not inhibited, but I would assume it’s still mostly good. You just add phosphorus, and, that should turn it all back into HI in solution. Are you saying it starts out yellow, and turns dark purple after 45 hrs reflux? My worry is capturing all the HI gas produced by dropping water on I2 + P. Take some of your dark purple solution and add sodium thiosulfate. If it’s iodine, that will destroy it. Just as a test, though. I’m not sure how to deal with iodine. You might not have to; I doubt it is carried over with the meth oil. It should stay behind in the water. I always suspected iodine together with acetone for making a nauseating smell. One source claims that the use of sodium hypophosphite in place of phosphorus generates a lot more of the deadly phosphine gas.
yes the hydriodic is yellow, i think the red phos has a dye in it or something. the first time i tried cooking i put the red phos in with out washing it, it turned the solution dark purple, after 45hrs reflux the solution was like a water like consistency. i based the solution to 13 or 14 and i didnt get an oil layer seperate from the solution.
i am concerned that some of my materials are not what i think, eg, the pseudo isnt pseudo or the red phos is red. actually i think the red phos looks more like gun powder, after i washed it with water, it settles on the bottom of the glass, when i empty the water and look closely at the phos it is a dark purple colour sand like stuff. some very fine bits and some larger bits.
after a couple of washes in water the red is clean and if i put in glass of water the water still remains clear.
i have got a small flask and condenser and hotplate, im gonna attempt another go with say 30grams pseudo, how long do you think i shud let it reflux? i have read somewere that 24hrs is enough time for a small batch.
whats your opinion on my red phos? does it sound like its red phos?
also do you know of any way that i can test pseudo to make sure its pseudo and not something else.
Put a little P on a spatula and hold it in a flame. It burns in air with a white smoke. It glows in the dark. Pseudo has a bitter taste. Get some from a pharm to familiarize yourself with the taste. Look up the mp, I believe ephedrine HCl melts at 216 C. Meth HCl melts at 170-175. HI 57% vapor should be dark and stain paper, the stain should be removed by 2 S2O32−(aq) + I2(aq) → S4O62−(aq) + 2 I−(aq).
If “hydriodic acid” is really HF, it will eat right through your flask and mantle, maybe kill you. The DEA loves that. The show, “Breaking Bad”, refers to it in the first episode obliquely. I don’t think batch size makes any difference to cooking time. Reflux is reflux. 24 hours is more than enough. https://sbillinghurst.wordpress.com/2010/06/13/merck-index-2/
very useful info, thanks man.
thanks man, how do i tell if the reaction is completed and cooking is done? what color should i see, or what signs should i look for.
thanks again
Let the batch cool down for sampling, pipette out 2 mL (contg. 1 1/2 g product), base over in a test tube w/ cool 50% NaOH. The vapor should make you high. Extract 3x w/ diethyl ether, combine extracts in an evaporating dish, neutralize w/ conc. HCl, let evaporate. The behavior of pure meth crystallizing is distinct. If a hot water solution of the maximum which will dissolve (one more drop of water makes it go from cloudy to clear) does not turn into real sharp crystals as it cools, it could be incomplete, and, it’s no use trying to separate meth from pseudo by fractional crystallization. The batch should then be cooked some more. If it crystallizes easily by dropping in a seed crystal, you are done.
thanks man, i will let you no how it goes. btw, what color should the reaction mix be after cooking?
hey man, after i finish 24hr reflux, i base the solution, my solution seperates, and the bottom layer is dirty black colour, the top is clear oily. however, after distillation, it still wont crystalize. whats your thoughts?
I need to know more about the simple way of cooking meth to avoid explosion.
How does the journey into the origin of meth starts, and why did people disregards the harmful effect of it, and still ventures in it?
How does the journey into the origin of meth starts, and why did people disregards the harmful effect of it, and still ventures in it?
Iam new here and wish to meet some great fans here.
Lets talk about meth. +2348065011743
@ sbillinghurst, afte cooking andi base the reaction mixture, it turns balck, with a oil layer seperating on the top, is this mormal?
As a hot reaction mixture, you can’t throw in flammable solvents. What do you think, pyco-pyco, or, nico-nico imaey? You let it cool down. Filter out all solids. I heat up again when I base. That reaction spits caustic. I can’t cool down. You got me spinnin’ round and round.
As the turbulence settles, an oil layer forms. Why? Bec “no longer an ion” means, “no longer dissolves in water”. It clings to itself; if it’s heavier than water, it sinks. If there’s no water, it sinks if it’s heavier than THAT. Of what? Of the solvent you put in there such that your 500mL water layer is now surmounted by 500 mL of a solvent layer contg the free amine base, an acrid, bitter, burning, mobile, evil and expensive liquid by itself.
If it doesn’t behave like that, and anything happens you are not sure of, such as liquids eating right through nglass even though they aren’t that hot, you probably got fluorides in the saqlab.
before base the colour was dark purple. (if i wash the red phos before i cook, then the colour before basing is pale yellow)
I think it’s all fine. After the reaction’s over and it is based and an oil layer floats off, the aqueous portion remaining is eventually discarded after being extracted. Each one of these extracts may be examined for contamination before combining them all. I might note that the very next improvement to the process is to retain the phosphorus filtered out for use in the next batch, and, to risk an attempt to recover HI. It’s risky in the sense that the product is recovered more indirectly. Something could happen to it; but, the added step is after the P is filtered out, and, before the caustic base is added, the batch is returned to the flask used for reflux, and, the set-up is reconfigured for downward distillation. The heating is resumed, much as before, but the acid will boil out and is captured in a receiver. It should be 57% HI. This combined with the P and stored should be stable and gets you a jump on the reagents for the next batch. However, this particular evidence is a “slam-dunk” case for manufacturing, as is any dope-soaked or starting-material containing lab equipment, so, get it out of there.
As the volume of residual acid containing all the product in this modification is reduced, perhaps water should be added such that extra-harsh conditions of heat and acidity do not rearrange product, I don’t know. In 1987, it was always possible to buy more acid and P. It was Gordon H. Alles who addressed the proper workup procedure regardless of the method by which the amphetamine was produced. Well, I mean, I think his was neutral, and, my concern is boiling acid to dryness may make everything in there turn green.
A computer was recently seized by the FBI which contained e-mails from me, so, to you new people, you ought to take steps to anonymize yourselves; this blog collects IP addresses. To the old users, I just hope you did not know as little about Internet anonymity as how to make speed.
Can you use acetone instead of H2S04
acetone’s a solvent, h2so4’s an acid. the solvent for acid is diethyl ether, the acid to use is hcl, but, i wonder where you saw this. i must have put a recipe in this post with no connection to me, and ppl quote it to me. it’s just to show you an example of a recipe which I did not write; they’re terrible. You can’t accidently say something intelligent. Please study.
seo st petersburg…
[…]Pseudoephedrine Acetate « How to Make Methamphetamine[…]…
I am keen to see more pictures of the instructions in the various more important stages of the making of Meth Amphetamine Sulphate. You’ve got to assume were all dumb individuals that wouldn’t have the first Idea about buying the assorted flasks one would need to make it.
Also can you please dumb down a lot the procedure for making Sudo Effedrine or I effedrine for novices like me who are keen to study this process in which a person makes Met Amphetamine Thank you.
I spent oodles of hours today on that. Checking out all these doohickies they used to sell tailor-made for the meth trade reveals the practice from the level of a toy on up.
im bored, i need to find something to do, a way to make more money. thinkin about going postal. do you live elsewhere, want a friend/partner, and posses ideas that could be helpful and benefit us? if so, let me know.
Don’t give up. If you have no reason to hate someone, show it by making it a little bit better, no matter how small. If you want to write to me, sbillinghurst@gmail.com. I’ll do business with you. What is it you want? That is, since you mentioned ídeas to benefit us, what is it that you can do to benefit us? Let me find out where you live.
Alaska? So, that’s the context for the boredom and the post office? You have six more months of sunlight now. Get over it. Please do not make me extract your information. Volunteer, and what the hell do you mean using such language? I want every post coming out of your keyboard to be lucid, sane, and upbeat from now on, or, I’ll drop you like a stale donut.
in philippines we called it shabu…it is profitable…politics, leaders, government agencies, mostly cops, if you’re not generous to them that’s the time you became stupid….
I see. We do not use “became” like you do, to immediately shift tracks to rewrite the person’s acts they did a long time ago. Makes one instantly guilty and is a nice trick to pass along. They’re not possible to say when we became stupid, or thus chose to do wrong as a way of life, being what we’re doing now, or else it would be so unbecoming, which means ugly.
currently
what am i sposed to mk frm the FAST AND THE FURIOUS, barmit? What about when i go to sunny mexico? If ppl are falling down, it is my breath? the only reason to join is the flies are flies, they were there all the time? They aren’t bullets/ They aren’t going to hook me up?
bubbly beaker keep away from the tweaker beth is a constant whore on meth+you thought it was crank you jerk it was a prank and if u take my bank and drain the account out, ill go crazy punch u and scream and shout. i doodle while i think of pesuodo, feeling high, feeling low, i suddenly wrap a bow in meth beth’s grimy hair, and watch all the dopeheads blatently stare. draino that aint a go. why isnt it called drainYES as i fiend out wishing i could punch u as i confess we have become the ones that have less. your caress is superficial and im about to bust out the pistol because even tho u literaly didnt put a gun to my head the 1st time i hit the glass, alas the tables are reversed, and its my turn to blast and cast assh0l3s like your dumbass out of site. i beat it.
Fight. fight fight. be the better person, beth. diassociate with Ms. Spun and cut the cursin’ and the threats of imagining you, your fellow man being loaded in a hurst. who wants to bet meth beth is gonna run, and live a life where shes got no soul left. How did you help the world today? Panhandling and asking hard honest peoples’ for their money? cAn’t get a job? Oh, now I know, Bob fired you. Your stupid excuse “he said i look like a morbidly obesed blob”, your lazy and it no longer phases me. you sure look like a slob. youre fully capable of walking. working, and thinking. and don’t forget to blink twice because when u go to bed tonight in that alley, those mice will gnaw and nibble at you until its no longer suffice. time to prepare a hit,pull out the rig and supply kit. you dont even care if you got HIV, using dirty needles, your a waste of human life and make zero effort to fight to stay alive. Zero to hero….scratch that. Do the world a favor and get a knife cause im the son of a beotch that with honors will take your wasted drug induced life. you r worse than crackheads. a crackhead would just steal my valuables, a tweaker would steal my valubles and have the audocity to help me waste time looking for it knowing fully well you got it you ccunt
youre no good. even hoodrats in the projects with nada have standards and behave well instead of you and that dumb hood you hide over your hideous face. Don’t sit next to me you look like you got leprosy biotch or some kind of flesh eating bacteria. you look sixty, and not to sound picky but your mouth is gross and iller than a muslim eating a hotdog at an african festival. im not laughing. dont mean to point out your flaws but i saw a skeleton in the hall and was appauled. then i remembered the grim reaper dont carry no beeper….then i hear beep! and like a creep theres your fragile figure lurking in the shadows watching that lesbo Rachel Maddow with your dope partner in crime Miguel.
Your holes in your shoes are atrousious. Even worse your socks popping thru are beyong the word gross. i bet sucker pedestrians feel bad and buy you sneakers only so you can turn around and sell them and continue being a rotten tweaker. How’s your teeth? i can see your cheeks caving in from beneath since u loss them all and just let them rot out and fall. you ever think of dentures? The venture in searching for a decent dentist would be will worth it. but who am i kidding, you dont give a flying shit.
why don’t you just quit. there’s no such thing as quitting bit by bit. you look ridiculous constantly lit. and i’ve had enough missy. So go run off with your loser dudeman Miguel, he’s no man he’s a damn sissy. You dont have to be a psychic to know that once you tap his ass out for dope youll move on to the next weak sucker. i want to say next weak muferfooker but maybe there wont be a next time. Enjoy your next line Miss Meth Beth cause once you burn all the briges in this town I know i’ll never see u again. It’ll be the end. So stop pretending nothings wrong. Youve been doing this way too long. I got my life to live….i must stay strong…and find happy clean people that show love and make me feel belonged. Thieves, cowards, cleptos, liars, borrowers, feeble-minded and druggies are not my type of people.
i cant help you.
all u do is lie
dont reach me til you get the help you need
and quit biting the hand that feeds
you will succeed
if u follow thru with the correct deeds
please please fight to get better
and when u do i cant wait to read your letter
call me crazy, call me unfair
but your sorrow has taken its toll and is not fair.
im getting tired its very late
i wish u knew how badly i worry about you fate…..
my bigggest fear is these 2 words: you and cremate.
please get help before its too late.
say no to dope…or there is no hope
you can sit there and mope and mope
i refuse to watch u to continue to fall further down the slope.
Either say nope or fight and keep the focus and cope
have your so-called street buddies poured theyre hearts out?
have you caused them to scream and shout?
sure u have, when ur clepto ass duked it out and left with a pout
there wont be a next time, just bang bang pow pow
and only a memory of your obituary ill read about
dont do it for me do it for you.
youll fail if your fighting for my tough love back
you can have it once youve proven….and quit losing.
i want to be happy with u not crappy
its now or your young life is on a short schedule.
go ahead, hate me, no 1 else has the balls to look at you and say what theyy see…..i do because i love u. even if the drugs make u hate me i know its the meth devil talking, not you.
mary
south los angeles
Ooh, thank you, thank you, thank you. Excel-LEN-te, Mary from L.A. I love content. I’ll read it later, gotta go, child alone.
–SEB
Hi Steve…any chance you want an intern in your lab/ I have a BS in Biochemistry and Cell Biology and I worked in “Drug Development & Discovery” at “Super Pharma X” for many years as a Research Scientest in the Lab. Most interested and impressed by your work and communication skills…
Well, I can’t give a yes-or-no answer. I don’t have a lab. My idea is to transfer the part we can’t work on to other sources. Once the information is obtained, it is safe to have. I’m willing to possess it. I’m not willing to set up experiments to obtain it. I’m high-profile. This is the problem: how to bring information to the public which is a crime to produce, but not to know. If you like, contact me by e-mail about not duplicating efforts, division of labor. Could you please produce a one-page essay on a topic of interest to this audience? BTW, I don’t pay.
Im so sick of everyone telling me speed or meth is bad. I know that….we all do. However for many years i used tiny amounts of it to give me energy boosts and this resulted in my business growing 5 x its rate. Now i want to make my own for myself. Not sell it or try make millions… I just want to have a better quality of life which it gave me at the time. Now im back to being normal and its pathetic. I have tried being normal for the last 5 years and lost my business and everyone in it. I operate at a much better level on a bit of speed…just like Hitler did and just like President Kennedy did. Speed brings my body to a reliable consistent rate and it also makes me depression free. Im currently now relying on duromine which is rubbish. I get 10 minutes of alertness and then all the head aches that come with it…and this crap is legal. wtf. Help me get back my better life without going to dealers.
There is nothing to quibble about when it comes to a choice between ephedrine and pseudoephedrine; it’s between (L)-ephedrine and (D)-pseudoephedrine on the one side, “compounds transformable to (D)-methamphetamine”, and, on the other, “cpds transformable to (L)-methamphetamine”. Of the two ephedrine isomers, only the L precursor will make the D product. Decongestants containing E or pseudo-E have the correct isomer. When ordering from a chemical company, don’t tell ’em you want to be sure and get the one that makes speed, which is too conspicuous. Tell them they better not try to sell you the one that doesn’t make speed, that you heard it’s no good for other reasons. In any case, celebrate like a big dog when you finally make it.
嗨，你好，谢谢你方便的话把 碘红磷合成麻黄碱计量温度及步骤！如果可以的话！谢谢你发到我邮箱！465618926@QQ.COM 有其他更好的方法的话也希望和你分享，谢谢
jeszcze odjąć wygraną również wyjechać zatem, najsympatyczniej Harrison bezpiecznie.
Owo miało znajdować się zadanie Arnolda. Von Egger
nie niepowodzenie wygłosił o
swych zjadliwych stosunkach z dworem. Przysięgał, że w otoczeniu króla m.
You are the woman who takes the name of 1718’s inventor of Antabuse.
still subtract win also leave therefore, najsympatyczniej Harrison safely.
That would be the task of Arnold. von Egger
failure is not made of
his virulent relations with the court. He swore that surrounded the King
Way where with your women?–I don’t use, dong-dong!
Welcome to Dow-Dow MetaPhetamine. Curies are looking for you.
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has anyone tried to extract pseudo from Cirus 120mg?
in Europe what is best OTC for extraction?
any safe and legitimit pseudo sites to order from
The following is an excerpt from a Forensic Science International paper in 2007:
“Methamphetamine was synthesized according to the method of Windahl [14] with slight modification. A solution of (+)-pseudoephedrine HCl (5.0 g), red phosphorus (0.1 g) and hydrochloric acid (10 mL) was heated under reflux at 130 °C for 5 h, followed by addition of distilled water (12 mL). After standing overnight at room temperature, the reaction mixture was rendered basic with addition of 20% NaOH (22 mL), then extracted with diethyl ether three times. Residual H2O from the ether extract was dried over MgSO4. Then methamphetamine was crystallized from the ether.”
I notice that they never used HI. Is this synthesis any good? They also didn’t report yield
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ini adalah cairan yang terikat asam (hcl) kemudian bercampur dengan Triprolidine hcl dikemas dalam botol syrup.
campuran tersebut berupa cairan dan bukan padat yang harus kita haluskan dengan blender kopi.
2- Apakah cairan tersebut harus kita tambah HCL untuk melepaskan cairan syrup dari “my Suzzy”, kemudian dibuat free base.
2- Bagaimana dengan Tripolidine yang base acid, apakah ikut juga dengan “Suzzy” yang juga base acid? pada saat dibuat free base?
Hmm, yeh, yeh, yeh, yeh. Not in time the way you put it. Leaving your issue under a newspaper, cause with Stepehn, yer not lyin’. Dyin’ isn’t a threat. Anytime is alright. Medical, Beaners.
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How do someone crystalize shake
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Amphetamine
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. DISCLAIMER: PW’s dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. |
Amphetamine (also known as alpha-methylphenethylamine, amfetamine, and speed) is a classical stimulant substance of the phenethylamine class. It is the parent compound of the substituted amphetamines, a diverse group that includes methamphetamine, MDMA, cathinone, and bupropion. The mechanism of action involves promoting release of the neurotransmitters dopamine and norepinephrine. [2]
It was first synthesized in 1887, but its psychostimulant effects were not discovered until 1929. [3] In the 1930s, it was sold over-the-counter under the name «Benzedrine» as a decongestant. [4] It became widely used to treat a range of ailments such as alcohol hangover, narcolepsy, depression, and obesity. [5] Due to issues with addiction and abuse, it was eventually listed as a controlled substance under the United Nations 1971 «Convention on Psychotropic Substances». [6]
Amphetamine is now primarily a prescription drug used to treat attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. [7] [8] Additionally, it sees widespread illicit use as a performance enhancing agent and recreational substance.
Subjective effects include stimulation, focus enhancement, motivation enhancement, increased libido, appetite suppression, and euphoria. It is usually taken orally, but can also be insufflated, injected, or administered rectally. Lower doses tend to increase focus and productivity while higher doses tend to increase sociability, sexual desire, and euphoria.
Amphetamine has high abuse potential. Chronic use (i.e. high dose, repeat administration) is associated with compulsive redosing, escalating tolerance, and psychological dependence. Additionally, abuse has been linked to a number of health conditions, especially cardiovascular issues such as high blood pressure and increased risk of stroke. [9]
It is highly advised to use harm reduction practices if using this substance.
Contents
History and culture
Amphetamine was first synthesized in Germany in 1887 by the Romanian chemist Lazăr Edeleanu, who named it phenylisopropylamine. [10] However, its stimulant effects remained unknown until 1927, when it was independently re-synthesized by Gordon Alles and discovered to have sympathomimetic properties. [11]
In late 1933, Smith, Kline and French began selling amphetamine in the form of a decongestant inhaler under the name Benzedrine. [4] Benzedrine sulfate was introduced 3 years later and was used to treat a wide variety of medical conditions, including narcolepsy, obesity, low blood pressure, low libido, and chronic pain. [12]
During World War II, amphetamine and methamphetamine were used extensively by both the Allied and Axis forces for their stimulant and performance-enhancing effects. [13] [14] As its addictive properties became known, governments began to place strict controls on its sale. [15]
Amphetamine is still illegally synthesized and sold on the black market, primarily in European countries. [16] Among European Union (EU) member states, 1.2 million young adults used illicit amphetamine or methamphetamine in 2013. During 2012, approximately 5.9 metric tons of illicit amphetamine were seized within EU member states; [16] the «street price» of illicit amphetamine within the EU ranged from €6–38 per gram during the same period. [16]
Outside Europe, the illicit market for amphetamine is much smaller than the market for methamphetamine and MDMA. [16]
Chemistry
Amphetamine, also known as alpha-methylphenethylamine, is a synthetic substance of the phenethylamine family. The chemical structure of amphetamine consists of phenethylamine, a phenyl ring bound to an amino (NH2) group through an ethyl chain, with an additional methyl substitution at Rα. The name ‘amphetamine’ is a contraction from αlphamethylphenethylamine
It is the parent compound of the substituted amphetamines, a highly diverse group that includes such substances as bupropion, phenmetrazine, methamphetamine, MDMA, and the DOx series.
At room temperature, the pure freebase is a mobile, colorless, and volatile liquid with a characteristically strong amine odor, and acrid, burning taste. [17]
Enantiomers
Amphetamine is a chiral compound. Racemic amphetamine (dl-amphetamine) contains two optical isomers, or enantiomers:
Adderall and many other formulations of mixed amphetamine salts contain the enantiomers in a 3:1 ratio of d to l. This is achieved by mixing one part racemic amphetamine and one part d-amphetamine.
Pharmacology
Amphetamine exerts its behavioural effects by increasing the signaling activity of neurotransmitters norepinephrine and dopamine in the reward and executive function pathways of the brain. The reinforcing and motivational effects of amphetamine are mostly due to enhanced dopaminergic activity in the mesolimbic pathway. [18]
The euphoric and locomotor-stimulating effects of amphetamine are dependent upon the magnitude and speed by which it increases synaptic dopamine and norepinephrine concentrations in the striatum. [3]
It is a potent full agonist of the trace amine-associated receptor 1 (TAAR1) and interacts with vesicular monoamine transporter 2 (VMAT2). [19] [20] [21] Combined action on TAAR1 and VMAT2 results in increased concentrations of dopamine and norepinephrine in the synapses, which stimulates neuronal activity.
Dextroamphetamine is a more potent agonist of TAAR1 than levoamphetamine. [22] Consequently, dextroamphetamine produces greater CNS stimulation than levoamphetamine, roughly three to four times more, but levoamphetamine has slightly stronger cardiovascular and peripheral effects. [23] [24]
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Visual effects
The visual effects of amphetamine are inconsistent and occur only mildly noticeable at higher doses. They are somewhat comparable to deliriant visuals and occur more readily in darker areas.
Distortions
It can get up to around 2.5-3 points on the psychonaut wiki scale. (click Traces above to read more)
Hallucinatory states
Cognitive effects
After effects
Experience reports
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.
As of March 2014, there is no evidence that amphetamine is directly neurotoxic in humans. [34] However, high-dose amphetamine can cause indirect neurotoxicity as a result of increased oxidative stress from reactive oxygen species and autoxidation of dopamine. [18] [35] [36]
In rodents and primates, sufficiently high doses of amphetamine causes damage to dopamine neurons, characterized as reduced transporter and receptor function. [37] Animal models of neurotoxicity from high-dose amphetamine exposure indicate that the occurrence of hyperpyrexia (i.e., core body temperature ≥ 40 °C) is necessary for the development of amphetamine-induced neurotoxicity. [38]
Melatonin has been shown to prevent (if used 30min+ before dosing) and reverse amphetamine induced neurotoxicity of TH-pSer40 and calpastatin levels in the Substantia Nigra of rats. [39] [40]
It is strongly recommended that one use harm reduction practices when using this substance.
Lethal dosage
The LD50 (the dosage required to kill 50% of the test subjects) of amphetamine in rats has been found to be between roughly 15 mg and 180 mg per kilogram, depending on the study. [41] No formal studies in humans have been carried out and the exact toxic dosage is unknown.
Dependence and abuse potential
Amphetamine has high abuse potential and can cause psychological dependence with chronic use.
When dependence has developed, cravings and withdrawal effects may occur if use is suddenly discontinued. [42] [43] Withdrawal symptoms include paranoia, depression, dream potentiation, anxiety, itching, mood swings, irritability, fatigue, insomnia, an intense craving for more amphetamine or other stimulants.
Addiction is a serious risk with chronic or heavy recreational amphetamine use, but is unlikely to arise from typical medical use. [44] [45] [46]
Amphetamine exhibits cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of amphetamine most stimulants will have a reduced effect.
Psychosis
Severe amphetamine overdose can result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, delusions). [47] A review on treatment for amphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely. [47] [48] The same review asserts that antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis. [47] Psychosis very rarely arises from therapeutic use. [49]
Dangerous interactions
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Reagent results
Exposing compounds to the reagents gives a colour change which is indicative of the compound under test.
Legal status
Internationally, amphetamine is a Schedule II controlled substance under the United Nations 1971 Convention on Psychotropic Substances. [53]